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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Development of CD4+ macrophages from intrathymic T cell progenitors is induced by thymic epithelial cells.

It was recently demonstrated that there are CD4(+) macrophages, which exhibit strong phagocytic activity, in the thymus. They are suggested to play an important role for the elimination of apoptotic thymocytes. However, the origin and nature of CD4(+) macrophages in the thymus remain unexplored. In this study, we describe that the most immature intrathymic progenitors (CD25(-)/CD44(+)/FcR(+)) give rise to CD4(+) macrophages by oncostatin M-responsive thymic epithelial cells (ORTEC) in an IL-7-dependent manner. Neither conditioned medium of ORTEC nor a mixture of cytokines induced CD4(+) macrophages, and oncostatin M receptor was not expressed in thymocytes, suggesting that the development of CD4(+) macrophages from the immature thymocytes requires a direct interaction with ORTEC. These results collectively suggest that the development of CD4(+) macrophages from the intrathymic T cell progenitors is induced by thymic epithelial cells.[1]

References

  1. Development of CD4+ macrophages from intrathymic T cell progenitors is induced by thymic epithelial cells. Esashi, E., Ito, H., Ishihara, K., Hirano, T., Koyasu, S., Miyajima, A. J. Immunol. (2004) [Pubmed]
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