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Gene Review:

Osmr - oncostatin M receptor

Mus musculus

Synonyms: IL-31 receptor subunit beta, IL-31R subunit beta, IL-31R-beta, IL-31RB, Interleukin-31 receptor subunit beta, ...

Tamura, S. et al., Tamura, S. et al., Esashi, E. et al., Bando, T. et al., Nakamura, K. et al., et al.

Tanaka, Hirabayashi, Sekiguchi, Inoue, Katsuki, Miyajima,

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High impact information on Osmr

Targeted disruption of oncostatin M receptor results in altered hematopoiesis [1].
Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice [2].
Neither conditioned medium of ORTEC nor a mixture of cytokines induced CD4(+) macrophages, and oncostatin M receptor was not expressed in thymocytes, suggesting that the development of CD4(+) macrophages from the immature thymocytes requires a direct interaction with ORTEC [3].
Complete overlap of interleukin-31 receptor A and oncostatin M receptor beta in the adult dorsal root ganglia with distinct developmental expression patterns [4].
Among them, the up-regulation of p-STAT3 and p-CREB may be induced possibly through OSMR [5].

Biological context of Osmr

Up-regulated phosphorylation of signal transducer and activator of transcription 3 and cyclic AMP-responsive element binding protein by peripheral inflammation in primary afferent neurons possibly through oncostatin M receptor [5].

Anatomical context of Osmr

Here, we investigated the expression of specific beta-subunit of oncostatin M receptor in the dorsal root ganglia of adult mice [6].
Approximately 13% of total dorsal root ganglia neurons in mice contained beta-subunit of oncostatin M receptor [6].
Seven days after sciatic nerve axotomy, the expression of beta-subunit of oncostatin M receptor was down-regulated in the lumbar dorsal root ganglia of the injured side [6].

Regulatory relationships of Osmr

In addition, all beta-subunit of oncostatin M receptor-positive neurons expressed both vanilloid receptor 1 and P2X3 purinergic receptor [6].

Other interactions of Osmr

Interestingly, OSMR-positive neurons with p-STAT3 and p-CREB were significantly increased after peripheral inflammation [5].
In the present study, we showed that OSM mRNA was highly expressed in the inflamed skin during acute inflammation induced by complete Freund's adjuvant (CFA), while the expression of oncostatin M receptor (OSMR) did not change in the ipsilateral DRG [5].

References

Targeted disruption of oncostatin M receptor results in altered hematopoiesis. Tanaka, M., Hirabayashi, Y., Sekiguchi, T., Inoue, T., Katsuki, M., Miyajima, A. Blood (2003) [Pubmed]
Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice. Nakamura, K., Nonaka, H., Saito, H., Tanaka, M., Miyajima, A. Hepatology (2004) [Pubmed]
Development of CD4+ macrophages from intrathymic T cell progenitors is induced by thymic epithelial cells. Esashi, E., Ito, H., Ishihara, K., Hirano, T., Koyasu, S., Miyajima, A. J. Immunol. (2004) [Pubmed]
Complete overlap of interleukin-31 receptor A and oncostatin M receptor beta in the adult dorsal root ganglia with distinct developmental expression patterns. Bando, T., Morikawa, Y., Komori, T., Senba, E. Neuroscience (2006) [Pubmed]
Up-regulated phosphorylation of signal transducer and activator of transcription 3 and cyclic AMP-responsive element binding protein by peripheral inflammation in primary afferent neurons possibly through oncostatin M receptor. Tamura, S., Morikawa, Y., Senba, E. Neuroscience (2005) [Pubmed]
Expression of oncostatin M receptor beta in a specific subset of nociceptive sensory neurons. Tamura, S., Morikawa, Y., Miyajima, A., Senba, E. Eur. J. Neurosci. (2003) [Pubmed]

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