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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Transmission of gametes with normal or translocation chromosomes in male and female single-sex mouse chimeras.

Three male and four female mouse single-sex chimeras derived from fusions of Rb(11.13)4Bnr T(1;13)70H homozygous embryos with +/+ embryos were caged with T(1;13)70H homozygotes of the opposite sex and followed through their reproductive lifespans. Six animals (three males and three females) were germline chimeras. The fz gene was used as a marker for the T70H reciprocal translocation. The ratio of fz/ fz to fz/+ offspring did not change with increasing age in males, but decreased in two of the three female chimeras. Within males, there was generally good agreement between the proportions of translocation and nontranslocation germ cells from spermatogonial mitosis through the first and second meiotic division. In one male, this ratio was also reflected in the offspring. In the other two males, there was significant selection during haplophase, from which both types of spermatozoa could benefit.[1]

References

  1. Transmission of gametes with normal or translocation chromosomes in male and female single-sex mouse chimeras. de Boer, P., van der Hoeven, F.A., Schöller, J.M. Cytogenet. Cell Genet. (1992) [Pubmed]
 
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