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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A case of atypical benign fibrous histiocytoma.

A case of atypical benign fibrous histiocytoma is reported. A 62-year-old Japanese female visited our clinic because of an asymptomatic solitary lesion on the skin of the left leg. Physical examination revealed a polypoid mass lesion (2.5 x 2.3 x 1.8 cm) with central erosion. The lesion began with a 1 mm-sized papule and slowly enlarged over the 20 years. Clinical diagnosis was a malignant tumor such as dermatofibrosarcoma protuberans, atypical fibroxanthoma or adnexal tumors. Biopsy of the polypoid lesion was carried out. Histopathological examination revealed a polypoid lesion consisting of proliferation of fibroblast-like spindle cells in the dermis. Large atypical cells with pleomorphic nuclei were occasionally observed but mitotic figures were rare. From immunohistochemical results (CD68, Factor-XIII, MIB-1 labeling index), we diagnosed this case as "atypical benign fibrous histiocytoma (ABFH)". Clear distinction has not been made between ABFH, a variant of benign fibrous histiocytoma, and atypical fibroxanthoma, which is a variant of malignant fibrous histiocytoma. Here we report a case of ABFH with a diagnosis of the neoplasm.[1]


  1. A case of atypical benign fibrous histiocytoma. Ikoma, N., Matsuyama, T., Nuruki, H., Iizuka, M., Umezawa, Y., Ohta, Y., Ozawa, A., Sekido, Y., Shimamura, K., Ueyama, Y. Tokai J. Exp. Clin. Med. (2004) [Pubmed]
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