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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Detection of anti-HLA-F antibodies in sera from cancer patients.

BACKGROUND: We previously reported that a Q5 gene product (Q5 antigen) on the surface of tumor cells caused humoral immune reaction in syngeneic tumor-bearing mice. Transcripts of the Q5 gene were observed in various tumor cells. The human counterpart of the Q5 gene has not been clarified yet. MATERIALS AND METHODS: Transcripts of human class Ib genes in various human tumor cell lines were analyzed by the RT-PCR method. Whether anti-HLA-F antibodies were present in sera from cancer patients was investigated through Western blotting with recombinant HLA-F as an antigen. RESULTS: Transcripts of the HLA-F gene were produced by various tumor cell lines. In addition, anti-HLA-F IgG was present in the sera derived from various types of cancer patients (26 positives / 42 tested), but not in the sera derived from healthy donors (0 / 20). CONCLUSION: Anti-HLA-F antibodies should be further investigated as possible diagnostic tumor markers.[1]

References

  1. Detection of anti-HLA-F antibodies in sera from cancer patients. Noguchi, K., Isogai, M., Kuwada, E., Noguchi, A., Goto, S., Egawa, K. Anticancer Res. (2004) [Pubmed]
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