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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Wave2 activates serum response element via its VCA region and functions downstream of Rac.

WAVE2 is a member of the WASP/WAVE family of protein effectors of actin reorganization and cell movement. In this report, we demonstrate that WAVE2 overexpression induces serum response element (SRE) activation through serum response factor. A WAVE2 mutant lacking the VCA region did not induce SRE activation and actin polymerization. WAVE2-induced SRE activation was blocked by exposure of cells to Latrunculin A, or overexpression of actin mutant R62D. The DeltaVCA mutant inhibited Rac V12-induced SRE activation, suggesting that WAVE2 lies downstream of Rac. Similar deletion of the VCA domain of WASP attenuated Cdc42 V12-mediated SRE activation, suggesting that WAVE2 acts in relation to Rac as WASP acts in relation to Cdc42. WAVE2 overexpression did not activate NF-kappaB.[1]

References

  1. Wave2 activates serum response element via its VCA region and functions downstream of Rac. Ishiguro, K., Cao, Z., Ilasca, M.L., Ando, T., Xavier, R. Exp. Cell Res. (2004) [Pubmed]
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