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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Manipulating the type 1 vs type 2 balance in type 1 diabetes.

Virus infections cause a strong inflammatory reaction that is dominated by the expression of type 1 cytokines and chemokines. Such an aggressive immune response by the host is necessary to eliminate intracellular pathogens. However, because of this shift in the type 1 vs type 2 balance of the immune response, virus infections are potential candidates for triggering autoimmune diseases, such as type 1 diabetes (T1D), herpes stromal keratitis, or multiple sclerosis ( MS). In this review we will focus on the pathogenesis of T1D in a virus-induced transgenic mouse model and discuss possibilities of how an aggressive type 1-dominated immune response can be restrained and autoimmunity be abrogated.[1]

References

  1. Manipulating the type 1 vs type 2 balance in type 1 diabetes. Christen, U., von Herrath, M.G. Immunol. Res. (2004) [Pubmed]
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