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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K.

Starting from the high-throughput screening hit 1a, novel cathepsin K inhibitors have been developed based on a purine scaffold. High-resolution X-ray structures of several derivatives have revealed the binding mode of these unique cysteine protease inhibitors.[1]

References

  1. Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K. Altmann, E., Cowan-Jacob, S.W., Missbach, M. J. Med. Chem. (2004) [Pubmed]
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