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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Interferon-gamma response of PBMC indicates productive pseudorabies virus (PRV) infection in swine.

In Chinese Meishan/German Landrace cross-bred swine F2 generation interferon gamma (IFN-gamma) production by peripheral blood mononuclear cells (PBMC) was determined directly ex vivo at different time points after survival of a virulent pseudorabies virus (PRV) infection. This reactivity was compared with the reactivity of naïve PBMC. Significant IFN-gamma production was determined in ELISA and ELISPOT only after in vitro PBMC re-stimulation with PRV and not with the closely related bovine herpesvirus BHV-1. The PRV-specific IFN-gamma secretion from re-stimulated PBMC showed high levels 6 days after infection, before the presence of serum antibodies, and it persisted at a high level over a 3 months period. The response of a group of eight piglets infected intranasally with PRV varied. Only two animals showed the expected typical fever response. PRV specific IFN-gamma production by PBMC clearly indicated that infection had occurred. Early significant IFN-gamma production by primed PBMC turned out to be a reliable and specific ex vivo marker for cellular response against productive PRV infection in swine before antibody formation.[1]


  1. Interferon-gamma response of PBMC indicates productive pseudorabies virus (PRV) infection in swine. Hoegen, B., Saalmüller, A., Röttgen, M., Rziha, H.J., Geldermann, H., Reiner, G., Pfaff, E., Büttner, M. Vet. Immunol. Immunopathol. (2004) [Pubmed]
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