The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

About

Terms

 

 
 

Genotoxic potential of cyproterone acetate: a possible role of reactive oxygen species.

The genotoxicity of cyproterone acetate was studied in human lymphocytes using chromosomal aberrations (CAs), mitotic index (MI) and sister chromatid exchanges (SCEs) as a parameter. Cyproterone acetate was found to be genotoxic at 20 and 30 microM. To study the possible mechanism of the genotoxicity of cyproterone acetate, superoxide dismutase (SOD) and catalase (CAT) were used separately and in combination along with the 30 microM of cyproterone acetate at different doses. SOD treatment increases CAs, SCEs and decreases MI as compared to treatment with 30 microM CPA alone, at both of the tested doses. CAT treatment decreases the frequencies of CAs and SCEs and increases MI in both, as compared to treatment with 30 microM CPA alone, separately and in combination with SOD, suggesting a possible role of reactive oxygen species for the genotoxic damage.[1]

References

  1. Genotoxic potential of cyproterone acetate: a possible role of reactive oxygen species. Siddique, Y.H., Afzal, M. Toxicology in vitro : an international journal published in association with BIBRA. (2005) [Pubmed]
Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities