- ET-1 induced bronchoconstriction in the early phase but not late phase of anesthetized dogs is inhibited by indomethacin and ICI 198615. Uchida, Y., Hamada, M., Kameyama, M., Ohse, H., Nomura, A., Hasegawa, S., Hirata, F. Biochem. Biophys. Res. Commun. (1992)