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Chemical Compound Review

CHEMBL22033     cyclopentyl N-[1-[[2-methoxy-4...

Synonyms: SureCN9806720, CHEBI:126784, ICI-198615, AC1L3GQZ, Ici-198,615, ...
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Disease relevance of Ici 198615


High impact information on Ici 198615


Biological context of Ici 198615

  • CONCLUSIONS: In vivo administration of the leukotriene receptor antagonist ICI 198,615 reversed the urodynamic changes induced by ovalbumin challenge in sensitized guinea pigs [8].
  • In pulmonary mechanics studies in which the effects of i.v. or aerosol administration of LTC4 and LTD4 on pulmonary resistance (Rp) or dynamic lung compliance (Cdyn) could be quantitated, ICI 198,615 provided dose-related antagonism when administered p.o., i.d, i.v. or by aerosol [1].
  • When sensitized lung fragments were treated with 5 mM AT-125, ICI-198,615 was effective in preventing not only antigen-but also LTC4-dependent production of TxB2 (IC50 = 0.018 and 0.021 microM, respectively) [9].
  • ET-1 induced bronchoconstriction in the early phase but not late phase of anesthetized dogs is inhibited by indomethacin and ICI 198615 [10].

Anatomical context of Ici 198615


Associations of Ici 198615 with other chemical compounds


Gene context of Ici 198615


Analytical, diagnostic and therapeutic context of Ici 198615

  • Arterial oxygen tension (PaO2) remained at baseline level of 20 +/- 1.0 kPa during the experimental period in both the nonseptic control group and the ICI 198,615 pretreated group [19].
  • When the dogs were pretreated with the intravenous injection of 0.1 micrograms/kg ICI 198615, an inhibitor of lipoxygenase, the constrictive response was slowed down [10].


  1. In vivo pharmacology of ICI 198,615: a novel, potent and selective peptide leukotriene antagonist. Krell, R.D., Giles, R.E., Yee, Y.K., Snyder, D.W. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  2. Beneficial effects of a leukotriene receptor antagonist on thrombin-induced pulmonary edema in the rat. Ahn, C.M., Sandler, H., Saldeen, T. Prostaglandins Leukot. Essent. Fatty Acids (1995) [Pubmed]
  3. Leukotriene D4 receptor antagonism reduces airway hyperresponsiveness in monkeys. Turner, C.R., Smith, W.B., Andresen, C.J., Swindell, A.C., Watson, J.W. Pulmonary pharmacology. (1994) [Pubmed]
  4. Functional studies of leukotriene receptors in vascular tissues. Walch, L., Norel, X., Gascard, J.P., Brink, C. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  5. Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma. Capra, V., Nicosia, S., Ragnini, D., Mezzetti, M., Keppler, D., Rovati, G.E. Mol. Pharmacol. (1998) [Pubmed]
  6. Leukotriene constriction of mouse pial arterioles in vivo is endothelium-dependent and receptor-mediated. Rosenblum, W.I., Nelson, G.H., Nishimura, H. Stroke (1990) [Pubmed]
  7. Binding of radiolabeled high affinity antagonist to leukotriene D4 receptor in guinea pig lung membranes: interconversion of agonist-receptor binding affinity states. O'Sullivan, B.P., Mong, S. Mol. Pharmacol. (1989) [Pubmed]
  8. Effects of the peptide leukotriene receptor antagonist ICI 198,615 on the in vivo and in vitro changes in guinea pig bladder function which occur after sensitization with ovalbumin. Lee, J.G., Levin, R.M., Krasnopolsky, L., Wein, A.J., Longhurst, P.A. J. Urol. (1995) [Pubmed]
  9. Evidence that peptidoleukotriene is a prerequisite for antigen-dependent thromboxane synthesis in IgG1-passively sensitized guinea pig lungs. Cheng, J.B., Pillar, J.S., Conklyn, M.J., Breslow, R., Shirley, J.T., Showell, H.J. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  10. ET-1 induced bronchoconstriction in the early phase but not late phase of anesthetized dogs is inhibited by indomethacin and ICI 198615. Uchida, Y., Hamada, M., Kameyama, M., Ohse, H., Nomura, A., Hasegawa, S., Hirata, F. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  11. Inhibition of antigen-induced contraction of guinea pig trachea by ICI 198,615. Redkar-Brown, D.G., Aharony, D. Eur. J. Pharmacol. (1989) [Pubmed]
  12. Evidence for two leukotriene receptor types in the guinea-pig isolated ileum. Gardiner, P.J., Abram, T.S., Cuthbert, N.J. Eur. J. Pharmacol. (1990) [Pubmed]
  13. Pharmacologic characterization of the contractile activity of peptide leukotrienes in guinea-pig pulmonary artery. Fedyna, J.S., Snyder, D.W., Aharony, D., Redkar-Brown, D., Krell, R.D. Prostaglandins (1990) [Pubmed]
  14. MDL 28,753, an agonist of LTD4 but an antagonist of LTC4 in longitudinal muscle of guinea pig ileum. Gieske, T.H., Sabol, J.S., Raddatz, R. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  15. Biochemical and pharmacological characterization of ICI 198,615: a peptide leukotriene receptor antagonist. Krell, R.D., Kusner, E.J., Aharony, D., Giles, R.E. Eur. J. Pharmacol. (1989) [Pubmed]
  16. Angiotensin II-mediated potentiation of endothelin-1-evoked bronchial contractions: a role for leukotrienes? Pitt, C.M., Nally, J.E. Pulmonary pharmacology & therapeutics. (1999) [Pubmed]
  17. Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle. Jonsson, E.W. Acta physiologica Scandinavica. Supplementum. (1998) [Pubmed]
  18. Agonist and antagonist activities of the leukotriene analogue BAY u9773 in guinea pig lung parenchyma. Wikström Jonsson, E., Rosenqvist, U., Dahlén, S.E. Eur. J. Pharmacol. (1998) [Pubmed]
  19. Leukotriene receptor antagonism prevents lung protein leakage and hypoxaemia in a septic cat model. Schützer, K.M., Larsson, A., Risberg, B., Falk, A. Eur. Respir. J. (1994) [Pubmed]
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