- Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype. Reinold, H., Ahmadi, S., Depner, U.B., Layh, B., Heindl, C., Hamza, M., Pahl, A., Brune, K., Narumiya, S., Müller, U., Zeilhofer, H.U. J. Clin. Invest. (2005)