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MeSH Review

Posterior Horn Cells

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Disease relevance of Posterior Horn Cells


High impact information on Posterior Horn Cells


Chemical compound and disease context of Posterior Horn Cells


Biological context of Posterior Horn Cells


Anatomical context of Posterior Horn Cells


Associations of Posterior Horn Cells with chemical compounds

  • The responses of single lumbar dorsal horn neurons to noxious radiant heat stimuli (50 degrees C, 10 sec) applied to glabrous footpad skin were recorded in cats anesthetized with sodium pentobarbital and 70% N2O [26].
  • In the presence of TTX, phorbol esters selectively enhanced, in a reversible manner, the depolarizing responses of dorsal horn neurons to N-methyl-D-aspartic acid and L-glutamate but not the responses to kainic or quisqualic acids [27].
  • Such transport block failed to alter thermal responsiveness of the rats as measured behaviorally, by the flexor reflex, or by dorsal horn cell responses [28].
  • The P2X receptors on acutely dissociated dorsal horn neurons are nondesensitizing, insensitive to alphabeta methylene ATP, and show strong but variable sensitivity to the antagonists suramin and pyridoxal-phosphate-6-azophenyl-2',4'-disulfonic acid (PPADS) [29].
  • Because earlier observations indicated that only nociceptive dorsal horn neurons respond to substance P (SP), we examined which morphological types of lamina I neurons express receptors for SP (NK-1r) [30].

Gene context of Posterior Horn Cells


Analytical, diagnostic and therapeutic context of Posterior Horn Cells


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  2. Role of kainate receptors in nociception. Ruscheweyh, R., Sandkühler, J. Brain Res. Brain Res. Rev. (2002) [Pubmed]
  3. Pain behavior and response properties of spinal dorsal horn neurons following experimental diabetic neuropathy in the rat: modulation by nitecapone, a COMT inhibitor with antioxidant properties. Pertovaara, A., Wei, H., Kalmari, J., Ruotsalainen, M. Exp. Neurol. (2001) [Pubmed]
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  11. Spinal administration of prostaglandin E(2) or prostaglandin F(2alpha) primarily produces mechanical hyperalgesia that is mediated by nociceptive specific spinal dorsal horn neurons. Turnbach, M.E., Spraggins, D.S., Randich, A. Pain (2002) [Pubmed]
  12. Inhibition of glutamate uptake in the spinal cord induces hyperalgesia and increased responses of spinal dorsal horn neurons to peripheral afferent stimulation. Weng, H.R., Chen, J.H., Cata, J.P. Neuroscience (2006) [Pubmed]
  13. Effects of intrathecally administered lamotrigine, a glutamate release inhibitor, on short- and long-term models of hyperalgesia in rats. Klamt, J.G. Anesthesiology (1998) [Pubmed]
  14. Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. Kawasaki, Y., Kohno, T., Zhuang, Z.Y., Brenner, G.J., Wang, H., Van Der Meer, C., Befort, K., Woolf, C.J., Ji, R.R. J. Neurosci. (2004) [Pubmed]
  15. Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis. Dinis, P., Charrua, A., Avelino, A., Yaqoob, M., Bevan, S., Nagy, I., Cruz, F. J. Neurosci. (2004) [Pubmed]
  16. Spinal neurons exhibiting a specific nociceptive response receive abundant substance P-containing synaptic contacts. De Koninck, Y., Ribeiro-da-Silva, A., Henry, J.L., Cuello, A.C. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  17. Synaptic transmission between dorsal root ganglion and dorsal horn neurons in culture: antagonism of monosynaptic excitatory postsynaptic potentials and glutamate excitation by kynurenate. Jahr, C.E., Jessell, T.M. J. Neurosci. (1985) [Pubmed]
  18. Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin. Suzuki, R., Rahman, W., Rygh, L.J., Webber, M., Hunt, S.P., Dickenson, A.H. Pain (2005) [Pubmed]
  19. Spinal substance P release in vivo during the induction of long-term potentiation in dorsal horn neurons. Afrah, A.W., Fiskå, A., Gjerstad, J., Gustafsson, H., Tjølsen, A., Olgart, L., Stiller, C.O., Hole, K., Brodin, E. Pain (2002) [Pubmed]
  20. Ca(2+)-dependent inactivation of NMDA receptors: fast kinetics and high Ca2+ sensitivity in rat dorsal horn neurons. Kyrozis, A., Albuquerque, C., Gu, J., MacDermott, A.B. J. Physiol. (Lond.) (1996) [Pubmed]
  21. The kv4.2 potassium channel subunit is required for pain plasticity. Hu, H.J., Carrasquillo, Y., Karim, F., Jung, W.E., Nerbonne, J.M., Schwarz, T.L., Gereau, R.W. Neuron (2006) [Pubmed]
  22. Antisense ablation of type I metabotropic glutamate receptor mGluR1 inhibits spinal nociceptive transmission. Young, M.R., Blackburn-Munro, G., Dickinson, T., Johnson, M.J., Anderson, H., Nakalembe, I., Fleetwood-Walker, S.M. J. Neurosci. (1998) [Pubmed]
  23. Motor neuron degeneration induced by excitotoxin agonists has features in common with those seen in the SOD-1 transgenic mouse model of amyotrophic lateral sclerosis. Ikonomidou, C., Qin Qin, Y., Labruyere, J., Olney, J.W. J. Neuropathol. Exp. Neurol. (1996) [Pubmed]
  24. Modulatory effects of estrogen and progesterone on colorectal hyperalgesia in the rat. Ji, Y., Tang, B., Traub, R.J. Pain (2005) [Pubmed]
  25. Synaptic mediation from cutaneous mechanical nociceptors. Schneider, S.P., Perl, E.R. J. Neurophysiol. (1994) [Pubmed]
  26. Serotonin involvement in descending inhibition of spinal nociceptive transmission produced by stimulation of medial diencephalon and basal forebrain. Carstens, E., MacKinnon, J.D., Guinan, M.J. J. Neurosci. (1983) [Pubmed]
  27. Multiple effects of phorbol esters in the rat spinal dorsal horn. Gerber, G., Kangrga, I., Ryu, P.D., Larew, J.S., Randic, M. J. Neurosci. (1989) [Pubmed]
  28. Alterations in the structure, function, and chemistry of C fibers following local application of vinblastine to the sciatic nerve of the rat. Fitzgerald, M., Woolf, C.J., Gibson, S.J., Mallaburn, P.S. J. Neurosci. (1984) [Pubmed]
  29. ATP P2X receptors mediate fast synaptic transmission in the dorsal horn of the rat spinal cord. Bardoni, R., Goldstein, P.A., Lee, C.J., Gu, J.G., MacDermott, A.B. J. Neurosci. (1997) [Pubmed]
  30. NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons of the primate spinal cord. Yu, X.H., Zhang, E.T., Craig, A.D., Shigemoto, R., Ribeiro-da-Silva, A., De Koninck, Y. J. Neurosci. (1999) [Pubmed]
  31. Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord. Ding, Y.Q., Yin, J., Kania, A., Zhao, Z.Q., Johnson, R.L., Chen, Z.F. Development (2004) [Pubmed]
  32. Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons. Brenner, G.J., Ji, R.R., Shaffer, S., Woolf, C.J. Eur. J. Neurosci. (2004) [Pubmed]
  33. Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. Karim, F., Wang, C.C., Gereau, R.W. J. Neurosci. (2001) [Pubmed]
  34. Intrathecal injection of GDNF and BDNF induces immediate early gene expression in rat spinal dorsal horn. Jongen, J.L., Haasdijk, E.D., Sabel-Goedknegt, H., van der Burg, J., Vecht, C.h.J., Holstege, J.C. Exp. Neurol. (2005) [Pubmed]
  35. Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. Wu, L.J., Duan, B., Mei, Y.D., Gao, J., Chen, J.G., Zhuo, M., Xu, L., Wu, M., Xu, T.L. J. Biol. Chem. (2004) [Pubmed]
  36. Suppression of a hind limb flexion withdrawal reflex by microinjection of glutamate or morphine into the periaqueductal gray in the rat. Carstens, E., Hartung, M., Stelzer, B., Zimmermann, M. Pain (1990) [Pubmed]
  37. Effects of Kelatorphan and morphine before and after noxious stimulation on immediate-early gene expression in rat spinal cord neurons. Tölle, T.R., Schadrack, J., Castro-Lopes, J.M., Evan, G., Roques, B.P., Zieglgänsberger, W. Pain (1994) [Pubmed]
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