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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Activin A inhibits differentiation of 3T3-L1 preadipocyte.

We investigated the effect of activin A on differentiation of 3T3-L1 preadipocyte. Activin A suppressed the induction of terminal differentiation markers such as glycerol-3-phosphate dehydrogenase (GPDH) activity, lipid accumulation, and the expression of adipocyte fatty acid-binding protein (aP2) mRNA when the cells were treated with activin A throughout the differentiation period. Activin A treatment during the early phase decreased GPDH activity and aP2 mRNA level, and also reduced the expression of peroxisome proliferator-activated receptor ( PPAR) gamma and CCAAT/enhancer binding protein (C/ EBP) alpha mRNAs without affecting the expressions of the active isoforms of C/EBPbeta and its mRNA. On the other hand, activin A treatment had no effect on the mitotic clonal expansion. These results indicate that activin A inhibits adipogenesis via affecting the transcriptional factor cascade upstream of PPARgamma expression.[1]

References

  1. Activin A inhibits differentiation of 3T3-L1 preadipocyte. Hirai, S., Yamanaka, M., Kawachi, H., Matsui, T., Yano, H. Mol. Cell. Endocrinol. (2005) [Pubmed]
 
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