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Gene Review

FABP12  -  fatty acid binding protein 12

Homo sapiens

Synonyms: Fatty acid-binding protein 12
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Disease relevance of LOC646486


Psychiatry related information on LOC646486


High impact information on LOC646486


Chemical compound and disease context of LOC646486


Biological context of LOC646486


Anatomical context of LOC646486


Associations of LOC646486 with chemical compounds


Physical interactions of LOC646486


Regulatory relationships of LOC646486


Other interactions of LOC646486


Analytical, diagnostic and therapeutic context of LOC646486


  1. Liver fatty acid-binding protein: a marker for studying cellular differentiation in gut epithelial neoplasms. Carroll, S.L., Roth, K.A., Gordon, J.I. Gastroenterology (1990) [Pubmed]
  2. Intestinal fatty acid-binding protein is a useful diagnostic marker for mesenteric infarction in humans. Kanda, T., Fujii, H., Tani, T., Murakami, H., Suda, T., Sakai, Y., Ono, T., Hatakeyama, K. Gastroenterology (1996) [Pubmed]
  3. An immunosensor based on disposable electrodes for rapid estimation of fatty acid-binding protein, an early marker of myocardial infarction. Schreiber, A., Feldbrügge, R., Key, G., Glatz, J.F., Spener, F. Biosensors & bioelectronics. (1997) [Pubmed]
  4. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Lieber, C.S. Alcohol (2004) [Pubmed]
  5. Assessment of coronary reperfusion in patients with myocardial infarction using fatty acid binding protein concentrations in plasma. de Groot, M.J., Muijtjens, A.M., Simoons, M.L., Hermens, W.T., Glatz, J.F. Heart (2001) [Pubmed]
  6. Understanding adipocyte differentiation. Gregoire, F.M., Smas, C.M., Sul, H.S. Physiol. Rev. (1998) [Pubmed]
  7. Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1). Lee, K., Villena, J.A., Moon, Y.S., Kim, K.H., Lee, S., Kang, C., Sul, H.S. J. Clin. Invest. (2003) [Pubmed]
  8. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. Baier, L.J., Sacchettini, J.C., Knowler, W.C., Eads, J., Paolisso, G., Tataranni, P.A., Mochizuki, H., Bennett, P.H., Bogardus, C., Prochazka, M. J. Clin. Invest. (1995) [Pubmed]
  9. Three distinct messenger RNA distribution patterns in human jejunal enterocytes. Li, W., Krasinski, S.D., Verhave, M., Montgomery, R.K., Grand, R.J. Gastroenterology (1998) [Pubmed]
  10. Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. Shepherd, P.R., Gnudi, L., Tozzo, E., Yang, H., Leach, F., Kahn, B.B. J. Biol. Chem. (1993) [Pubmed]
  11. Angiotensin II receptor antagonist reduces urinary liver-type fatty acid-binding protein levels in patients with diabetic nephropathy and chronic renal failure. Nakamura, T., Sugaya, T., Koide, H. Diabetologia (2007) [Pubmed]
  12. Unlike type 2 diabetes, type 1 does not interact with the codon 54 polymorphism of the fatty acid binding protein 2 gene. Georgopoulos, A., Aras, O., Noutsou, M., Tsai, M.Y. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  13. Demonstration of ischemia-reperfusion injury separate from postoperative infarction in coronary artery bypass graft patients. Fransen, E.J., Maessen, J.G., Hermens, W.T., Glatz, J.F. Ann. Thorac. Surg. (1998) [Pubmed]
  14. Combined hyperlipidemia is associated with increased exercise-induced muscle protein release which is improved by triglyceride-lowering intervention. Smit, J.W., De Bruin, T.W., Eekhoff, E.M., Glatz, J., Erkelens, D.W. Metab. Clin. Exp. (1999) [Pubmed]
  15. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Makowski, L., Boord, J.B., Maeda, K., Babaev, V.R., Uysal, K.T., Morgan, M.A., Parker, R.A., Suttles, J., Fazio, S., Hotamisligil, G.S., Linton, M.F. Nat. Med. (2001) [Pubmed]
  16. The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation. Shum, B.O., Mackay, C.R., Gorgun, C.Z., Frost, M.J., Kumar, R.K., Hotamisligil, G.S., Rolph, M.S. J. Clin. Invest. (2006) [Pubmed]
  17. Discrimination between myocardial and skeletal muscle injury by assessment of the plasma ratio of myoglobin over fatty acid-binding protein. Van Nieuwenhoven, F.A., Kleine, A.H., Wodzig, W.H., Hermens, W.T., Kragten, H.A., Maessen, J.G., Punt, C.D., Van Dieijen, M.P., Van der Vusse, G.J., Glatz, J.F. Circulation (1995) [Pubmed]
  18. Chimeric-transgenic mice represent a powerful tool for studying how the proliferation and differentiation programs of intestinal epithelial cell lineages are regulated. Hermiston, M.L., Green, R.P., Gordon, J.I. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  19. Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes. Hunt, C.R., Ro, J.H., Dobson, D.E., Min, H.Y., Spiegelman, B.M. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  20. Members of the fatty acid binding protein family are differentiation factors for the mammary gland. Yang, Y., Spitzer, E., Kenney, N., Zschiesche, W., Li, M., Kromminga, A., Müller, T., Spener, F., Lezius, A., Veerkamp, J.H. J. Cell Biol. (1994) [Pubmed]
  21. Spatial differentiation of the intestinal epithelium: analysis of enteroendocrine cells containing immunoreactive serotonin, secretin, and substance P in normal and transgenic mice. Roth, K.A., Gordon, J.I. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  22. Cellular metabolism and activation of retinoids: roles of cellular retinoid-binding proteins. Ross, A.C. FASEB J. (1993) [Pubmed]
  23. 15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells. Shappell, S.B., Gupta, R.A., Manning, S., Whitehead, R., Boeglin, W.E., Schneider, C., Case, T., Price, J., Jack, G.S., Wheeler, T.M., Matusik, R.J., Brash, A.R., Dubois, R.N. Cancer Res. (2001) [Pubmed]
  24. Spontaneous and protein-mediated sterol transfer between intracellular membranes. Frolov, A., Woodford, J.K., Murphy, E.J., Billheimer, J.T., Schroeder, F. J. Biol. Chem. (1996) [Pubmed]
  25. Phenylalanine side chain behavior of the intestinal fatty acid-binding protein: the effect of urea on backbone and side chain stability. Li, H., Frieden, C. J. Biol. Chem. (2005) [Pubmed]
  26. S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes. Ruse, M., Broome, A.M., Eckert, R.L. J. Invest. Dermatol. (2003) [Pubmed]
  27. Thiazolidinediones and glucocorticoids synergistically induce differentiation of human adipose tissue stromal cells: biochemical, cellular, and molecular analysis. Halvorsen, Y.D., Bond, A., Sen, A., Franklin, D.M., Lea-Currie, Y.R., Sujkowski, D., Ellis, P.N., Wilkison, W.O., Gimble, J.M. Metab. Clin. Exp. (2001) [Pubmed]
  28. Expression of human liver fatty acid-binding protein in Escherichia coli and comparative analysis of its binding characteristics with muscle fatty acid-binding protein. Maatman, R.G., van Moerkerk, H.T., Nooren, I.M., van Zoelen, E.J., Veerkamp, J.H. Biochim. Biophys. Acta (1994) [Pubmed]
  29. The effect of weight reduction on skeletal muscle UCP2 and UCP3 mRNA expression and UCP3 protein content in Type II diabetic subjects. Schrauwen, P., Schaart, G., Saris, W.H., Slieker, L.J., Glatz, J.F., Vidal, H., Blaak, E.E. Diabetologia (2000) [Pubmed]
  30. The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP. Münz, M., Zeidler, R., Gires, O. Cancer Lett. (2005) [Pubmed]
  31. Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation. Nadauld, L.D., Sandoval, I.T., Chidester, S., Yost, H.J., Jones, D.A. J. Biol. Chem. (2004) [Pubmed]
  32. Postprandial responses of individual fatty acids in subjects homozygous for the threonine- or alanine-encoding allele in codon 54 of the intestinal fatty acid binding protein 2 gene. Agren, J.J., Vidgren, H.M., Valve, R.S., Laakso, M., Uusitupa, M.I. Am. J. Clin. Nutr. (2001) [Pubmed]
  33. Fat depot-specific characteristics are retained in strains derived from single human preadipocytes. Tchkonia, T., Giorgadze, N., Pirtskhalava, T., Thomou, T., DePonte, M., Koo, A., Forse, R.A., Chinnappan, D., Martin-Ruiz, C., von Zglinicki, T., Kirkland, J.L. Diabetes (2006) [Pubmed]
  34. Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor gamma interactively influence insulin sensitivity and body composition in males. Damcott, C.M., Moffett, S.P., Feingold, E., Barmada, M.M., Marshall, J.A., Hamman, R.F., Ferrell, R.E. Metab. Clin. Exp. (2004) [Pubmed]
  35. Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9). Kerkhoff, C., Klempt, M., Sorg, C. Biochim. Biophys. Acta (1998) [Pubmed]
  36. Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells. Prasad, N.B., Biankin, A.V., Fukushima, N., Maitra, A., Dhara, S., Elkahloun, A.G., Hruban, R.H., Goggins, M., Leach, S.D. Cancer Res. (2005) [Pubmed]
  37. Three-dimensional structure of recombinant human muscle fatty acid-binding protein. Zanotti, G., Scapin, G., Spadon, P., Veerkamp, J.H., Sacchettini, J.C. J. Biol. Chem. (1992) [Pubmed]
  38. Rabbit heart fatty acid-binding protein. Isolation, characterization, and application of a monoclonal antibody. Knowlton, A.A., Burrier, R.E., Brecher, P. Circ. Res. (1989) [Pubmed]
  39. Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin. Harada, N., Miyoshi, H., Murai, N., Oshima, H., Tamai, Y., Oshima, M., Taketo, M.M. Cancer Res. (2002) [Pubmed]
  40. Human liver fatty acid binding protein. Isolation of a full length cDNA and comparative sequence analyses of orthologous and paralogous proteins. Lowe, J.B., Boguski, M.S., Sweetser, D.A., Elshourbagy, N.A., Taylor, J.M., Gordon, J.I. J. Biol. Chem. (1985) [Pubmed]
  41. The polymorphism at codon 54 of the FABP2 gene increases fat absorption in human intestinal explants. Levy, E., Ménard, D., Delvin, E., Stan, S., Mitchell, G., Lambert, M., Ziv, E., Feoli-Fonseca, J.C., Seidman, E. J. Biol. Chem. (2001) [Pubmed]
  42. 3-phosphoinositide-dependent protein kinase-1 activates the peroxisome proliferator-activated receptor-gamma and promotes adipocyte differentiation. Yin, Y., Yuan, H., Wang, C., Pattabiraman, N., Rao, M., Pestell, R.G., Glazer, R.I. Mol. Endocrinol. (2006) [Pubmed]
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