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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation.

The newly identified TIM family of proteins is associated with regulation of T helper type 1 (T(H)1) and T(H)2 immune responses. TIM-1 is genetically linked to asthma and is a receptor for hepatitis A virus, but the endogenous ligand of TIM-1 is not known. Here we show that TIM-4, which is expressed by antigen-presenting cells, is the ligand for TIM-1. In vivo administration of either soluble TIM-1-immunoglobulin (TIM-1- Ig) fusion protein or TIM-4-Ig fusion protein resulted in hyperproliferation of T cells, and TIM-4-Ig costimulated T cell proliferation mediated by CD3 and CD28 in vitro. These data suggest that the TIM-1-TIM-4 interaction is involved in regulating T cell proliferation.[1]

References

  1. TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Meyers, J.H., Chakravarti, S., Schlesinger, D., Illes, Z., Waldner, H., Umetsu, S.E., Kenny, J., Zheng, X.X., Umetsu, D.T., DeKruyff, R.H., Strom, T.B., Kuchroo, V.K. Nat. Immunol. (2005) [Pubmed]
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