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MeSH Review

Hepatitis A

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Disease relevance of Hepatitis A


High impact information on Hepatitis A

  • Steroid therapy in severe viral hepatitis. A double-blind, randomized trial of methyl-prednisolone versus placebo [6].
  • TIM-1 is genetically linked to asthma and is a receptor for hepatitis A virus, but the endogenous ligand of TIM-1 is not known [7].
  • The human homolog of TIM-1 is the hepatitis A virus (HAV) receptor, which may explain the inverse relationship between HAV infection and the development of atopy [8].
  • Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes [9].
  • We tested the hypotheses that the risk of asthma is reduced by intestinal parasites or hepatitis A infection, and increased by exposure to dust-mite allergen or organophosphorus insecticides in urban and rural areas of Jimma, Ethiopia [10].

Chemical compound and disease context of Hepatitis A


Biological context of Hepatitis A


Anatomical context of Hepatitis A


Gene context of Hepatitis A


Analytical, diagnostic and therapeutic context of Hepatitis A


  1. A controlled trial of a formalin-inactivated hepatitis A vaccine in healthy children. Werzberger, A., Mensch, B., Kuter, B., Brown, L., Lewis, J., Sitrin, R., Miller, W., Shouval, D., Wiens, B., Calandra, G. N. Engl. J. Med. (1992) [Pubmed]
  2. Extrinsic modulation of human T-lymphocyte E rosette function associated with prolonged hepatocellular injury after viral hepatitis. Chisari, F.V., Routenberg, J.A., Fiala, M., Edgington, T.S. J. Clin. Invest. (1977) [Pubmed]
  3. Controlled trials of charcoal hemoperfusion and prognostic factors in fulminant hepatic failure. O'Grady, J.G., Gimson, A.E., O'Brien, C.J., Pucknell, A., Hughes, R.D., Williams, R. Gastroenterology (1988) [Pubmed]
  4. Acute parvovirus B19 infection associated with fulminant hepatitis of favourable prognosis in young children. Sokal, E.M., Melchior, M., Cornu, C., Vandenbroucke, A.T., Buts, J.P., Cohen, B.J., Burtonboy, G. Lancet (1998) [Pubmed]
  5. Non-A, non-B hepatitis in West London. Farrow, L.J., Stewart, J.S., Stern, H., Clifford, R.E., Smith, H.G., Zuckerman, A.J. Lancet (1981) [Pubmed]
  6. Steroid therapy in severe viral hepatitis. A double-blind, randomized trial of methyl-prednisolone versus placebo. Gregory, P.B., Knauer, C.M., Kempson, R.L., Miller, R. N. Engl. J. Med. (1976) [Pubmed]
  7. TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Meyers, J.H., Chakravarti, S., Schlesinger, D., Illes, Z., Waldner, H., Umetsu, S.E., Kenny, J., Zheng, X.X., Umetsu, D.T., DeKruyff, R.H., Strom, T.B., Kuchroo, V.K. Nat. Immunol. (2005) [Pubmed]
  8. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. McIntire, J.J., Umetsu, S.E., Akbari, O., Potter, M., Kuchroo, V.K., Barsh, G.S., Freeman, G.J., Umetsu, D.T., DeKruyff, R.H. Nat. Immunol. (2001) [Pubmed]
  9. Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes. Bartosch, B., Dubuisson, J., Cosset, F.L. J. Exp. Med. (2003) [Pubmed]
  10. Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: a nested case-control study. Scrivener, S., Yemaneberhan, H., Zebenigus, M., Tilahun, D., Girma, S., Ali, S., McElroy, P., Custovic, A., Woodcock, A., Pritchard, D., Venn, A., Britton, J. Lancet (2001) [Pubmed]
  11. Hepatitis A in three patients taking sodium valproate. Dowling, S.J. Lancet (1984) [Pubmed]
  12. Utilization of the quantitative assay of lipoprotein X in the differential diagnosis of extraphepatic obstructive jaundice and intrahepatic diseases. Magnani, H.N., Alaupovic, P. Gastroenterology (1976) [Pubmed]
  13. Isoniazid-rifampin fulminant hepatitis. A possible consequence of the enhancement of isoniazid hepatotoxicity by enzyme induction. Pessayre, D., Bentata, M., Degott, C., Nouel, O., Miguet, J.P., Rueff, B., Benhamou, J.P. Gastroenterology (1977) [Pubmed]
  14. Identification of a surface glycoprotein on African green monkey kidney cells as a receptor for hepatitis A virus. Kaplan, G., Totsuka, A., Thompson, P., Akatsuka, T., Moritsugu, Y., Feinstone, S.M. EMBO J. (1996) [Pubmed]
  15. Hepatitis type A and hemodialysis: a seroepidemiologic study in 15 U.S. centers. Szmuness, W., Dienstag, J.L., Purcell, R.H., Prince, A.M., Stevens, C.E., Levine, R.W. Ann. Intern. Med. (1977) [Pubmed]
  16. Excellent response rate to a double dose of the combined hepatitis A and B vaccine in previous nonresponders to hepatitis B vaccine. Cardell, K., Akerlind, B., Sällberg, M., Frydén, A. J. Infect. Dis. (2008) [Pubmed]
  17. A hepatitis A virus deletion mutant which lacks the first pyrimidine-rich tract of the 5' nontranslated RNA remains virulent in primates after direct intrahepatic nucleic acid transfection. Shaffer, D.R., Emerson, S.U., Murphy, P.C., Govindarajan, S., Lemon, S.M. J. Virol. (1995) [Pubmed]
  18. Interaction of poly(rC) binding protein 2 with the 5' noncoding region of hepatitis A virus RNA and its effects on translation. Graff, J., Cha, J., Blyn, L.B., Ehrenfeld, E. J. Virol. (1998) [Pubmed]
  19. Patterns of shedding of hepatitis A virus antigen in feces and of antibody responses in patients with naturally acquired type A hepatitis. Mao, J.S., Yu, P.H., Ding, Z.S., Chen, N.L., Huang, B.Z., Xie, R.Y., Chai, S.A. J. Infect. Dis. (1980) [Pubmed]
  20. Inhibitory effects of atropine, protamine, and their combination on hepatitis A virus replication in PLC/PRF/5 cells. Biziagos, E., Crance, J.M., Passagot, J., Deloince, R. Antimicrob. Agents Chemother. (1990) [Pubmed]
  21. Solid-phase antibody capture hemadsorption assay for detection of hepatitis A virus immunoglobulin M antibodies. Summers, P.L., Dubois, D.R., Cohen, W.H., Macarthy, P.O., Binn, L.N., Sjogren, M.H., Snitbhan, R., Innis, B.L., Eckels, K.H. J. Clin. Microbiol. (1993) [Pubmed]
  22. Identification of hepatitis A virus as a trigger for autoimmune chronic hepatitis type 1 in susceptible individuals. Vento, S., Garofano, T., Di Perri, G., Dolci, L., Concia, E., Bassetti, D. Lancet (1991) [Pubmed]
  23. Histopathology of alpha 1-antitrypsin liver disease in a transgenic mouse model. Geller, S.A., Nichols, W.S., Dycaico, M.J., Felts, K.A., Sorge, J.A. Hepatology (1990) [Pubmed]
  24. Human lymphocyte responses to hepatitis A virus-infected cells: interferon production and lysis of infected cells. Kurane, I., Binn, L.N., Bancroft, W.H., Ennis, F.A. J. Immunol. (1985) [Pubmed]
  25. Hospital-based diagnosis of hemorrhagic fever, encephalitis, and hepatitis in Cambodian children. Chhour, Y.M., Ruble, G., Hong, R., Minn, K., Kdan, Y., Sok, T., Nisalak, A., Myint, K.S., Vaughn, D.W., Endy, T.P. Emerging Infect. Dis. (2002) [Pubmed]
  26. Hepatitis A virus suppresses RIG-I-mediated IRF-3 activation to block induction of beta interferon. Fensterl, V., Grotheer, D., Berk, I., Schlemminger, S., Vallbracht, A., Dotzauer, A. J. Virol. (2005) [Pubmed]
  27. Plasminogen activators and plasminogen activator inhibitors in liver deficiencies caused by chronic alcoholism or infectious hepatitis. Tran-Thang, C., Fasel-Felley, J., Pralong, G., Hofstetter, J.R., Bachmann, F., Kruithof, E.K. Thromb. Haemost. (1989) [Pubmed]
  28. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. Ichimura, T., Bonventre, J.V., Bailly, V., Wei, H., Hession, C.A., Cate, R.L., Sanicola, M. J. Biol. Chem. (1998) [Pubmed]
  29. The Cys-rich region of hepatitis A virus cellular receptor 1 is required for binding of hepatitis A virus and protective monoclonal antibody 190/4. Thompson, P., Lu, J., Kaplan, G.G. J. Virol. (1998) [Pubmed]
  30. Serum immunoglobulin levels in acute A, B, and non-A, non-B hepatitis. Zhuang, H., Kaldor, J., Locarnini, S.A., Gust, I.D. Gastroenterology (1982) [Pubmed]
  31. A functional polymorphism in the IL-10 promoter influences the response after vaccination with HBsAg and hepatitis A. Höhler, T., Reuss, E., Freitag, C.M., Schneider, P.M. Hepatology (2005) [Pubmed]
  32. In situ hybridization studies of hepatitis A viral RNA in patients with acute hepatitis A. Taylor, M., Goldin, R.D., Ladva, S., Scheuer, P.J., Thomas, H.C. J. Hepatol. (1994) [Pubmed]
  33. A cross-over pharmacokinetic study of a double viral inactivated factor IX concentrate (15 nm filtration and SD) compared to a SD factor IX concentrate. Goudemand, J., Peynet, J., Chambost, H., Négrier, C., Briquel, M.E., Claeyssens, S., Derlon-Borel, A., Guérois, C., Caron, C., Scherrmann, J.M., Debray, M., Bridey, F. Thromb. Haemost. (1998) [Pubmed]
  34. Determination of immunoglobulin M antibodies against hepatitis B core antigen and hepatitis A virus by reorienting sucrose gradient high-speed centrifugation for diagnosis of acute viral-hepatitis. Swenson, P.D., Escobar, M.R., Galen, E.A., Carithers, R.L. J. Clin. Microbiol. (1981) [Pubmed]
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