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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Clinical inquiries. Does anticoagulation prevent thrombosis for persons with fractures distal to the hip?

Low-molecular-weight heparin (LMWH) prophylaxis significantly reduces the total incidence of deep venous thrombosis (DVT) for patients with lower-limb fractures managed with surgical fixation and cast immobilization (strength of recommendation [SOR]: A, based on multiple randomized controlled studies [RCTs]). Evidence is insufficient to show whether LMWH specifically reduces the risk of clinically significant DVTs, and recommendations on its use are conflicting (SOR: C, based on expert opinion). Evidence is insufficient to recommend for or against warfarin prophylaxis for DVT in fractures distal to the hip (SOR: C, based on expert opinion).[1]

References

  1. Clinical inquiries. Does anticoagulation prevent thrombosis for persons with fractures distal to the hip? Brogen, J., Kelsberg, G., Safranek, S., Nadalo, D., Janki, P. The Journal of family practice. (2005) [Pubmed]
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