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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Thrombosis


Psychiatry related information on Thrombosis


High impact information on Thrombosis

  • It also acts at the onset of adverse clinical vascular events, when activated cells within the plaque secrete matrix proteases that degrade extracellular matrix proteins and weaken the fibrous cap, leading to rupture and thrombus formation [9].
  • Protease-activated receptors (PARs) are a unique class of G protein-coupled receptors that play critical roles in thrombosis, inflammation, and vascular biology [10].
  • We show that NO inhibits exocytosis of Weibel-Palade bodies, endothelial granules that mediate vascular inflammation and thrombosis, by regulating the activity of N-ethylmaleimide-sensitive factor (NSF) [11].
  • BACKGROUND: Impairment of the protein C anticoagulation pathway is critical to the thrombosis associated with sepsis and to the development of purpura fulminans in meningococcemia [5].
  • BACKGROUND: Cerebral sinovenous thrombosis in children is a serious disorder, and information is needed about its prevention and treatment [12].

Chemical compound and disease context of Thrombosis


Biological context of Thrombosis


Anatomical context of Thrombosis


Gene context of Thrombosis

  • Our data suggest that the determination of protein S levels will be useful in the evaluation of patients with recurrent thrombosis [33].
  • These findings warrant further evaluation of the possible therapeutic use of Gas6 inhibition for prevention of thrombosis [34].
  • Here we show that ablation of the mouse Sult1e1 gene caused placental thrombosis and spontaneous fetal loss [35].
  • Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction [36].
  • CONTEXT: New bolus fibrinolytics derived from the human tissue-type plasminogen activator (tPA) have emerged as a means of dissolution of occlusive thrombosis associated with acute myocardial infarction [37].
  • MRNA expression analysis showed an exclusive synthesis of tPA and PAI-1 within the wall, whereas uPA mRNA was also expressed within the thrombus [38].
  • In the tissue factor-mediated pathway, vWF plays a role in platelet accumulation during thrombus formation but is not required for platelet activation in vivo [39].
  • These data suggest that targeting the p38 MAPK pathway may be valuable in designing new therapy modalities for treating thrombosis in patients with APS [40].
  • Inhibition of the NK1 receptor may therefore provide benefit in patients vulnerable to thrombosis and may offer an alternative therapeutic target [41].
  • The ablation of in vitro thrombus formation in Prkca-/- platelets was rescued by the addition of ADP, consistent with the key mechanistic finding that dense-granule biogenesis and secretion depend upon PKCalpha expression [42].

Analytical, diagnostic and therapeutic context of Thrombosis


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  3. Localized intracoronary gamma-radiation therapy to inhibit the recurrence of restenosis after stenting. Leon, M.B., Teirstein, P.S., Moses, J.W., Tripuraneni, P., Lansky, A.J., Jani, S., Wong, S.C., Fish, D., Ellis, S., Holmes, D.R., Kerieakes, D., Kuntz, R.E. N. Engl. J. Med. (2001) [Pubmed]
  4. Effects of a low-molecular-weight heparin on thrombus regression and recurrent thromboembolism in patients with deep-vein thrombosis. Breddin, H.K., Hach-Wunderle, V., Nakov, R., Kakkar, V.V. N. Engl. J. Med. (2001) [Pubmed]
  5. Dysfunction of endothelial protein C activation in severe meningococcal sepsis. Faust, S.N., Levin, M., Harrison, O.B., Goldin, R.D., Lockhart, M.S., Kondaveeti, S., Laszik, Z., Esmon, C.T., Heyderman, R.S. N. Engl. J. Med. (2001) [Pubmed]
  6. Increase in atherosclerosis and adventitial mast cells in cocaine abusers: an alternative mechanism of cocaine-associated coronary vasospasm and thrombosis. Kolodgie, F.D., Virmani, R., Cornhill, J.F., Herderick, E.E., Smialek, J. J. Am. Coll. Cardiol. (1991) [Pubmed]
  7. Prevention of deep vein thrombosis after major knee surgery--a randomized, double-blind trial comparing a low molecular weight heparin fragment (enoxaparin) to placebo. Leclerc, J.R., Geerts, W.H., Desjardins, L., Jobin, F., Laroche, F., Delorme, F., Haviernick, S., Atkinson, S., Bourgouin, J. Thromb. Haemost. (1992) [Pubmed]
  8. Homocysteine, vitamins, and prevention of vascular disease. McCully, K.S. Military medicine. (2004) [Pubmed]
  9. Cytokines in atherosclerosis: pathogenic and regulatory pathways. Tedgui, A., Mallat, Z. Physiol. Rev. (2006) [Pubmed]
  10. PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Boire, A., Covic, L., Agarwal, A., Jacques, S., Sherifi, S., Kuliopulos, A. Cell (2005) [Pubmed]
  11. Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor. Matsushita, K., Morrell, C.N., Cambien, B., Yang, S.X., Yamakuchi, M., Bao, C., Hara, M.R., Quick, R.A., Cao, W., O'Rourke, B., Lowenstein, J.M., Pevsner, J., Wagner, D.D., Lowenstein, C.J. Cell (2003) [Pubmed]
  12. Cerebral sinovenous thrombosis in children. deVeber, G., Andrew, M., Adams, C., Bjornson, B., Booth, F., Buckley, D.J., Camfield, C.S., David, M., Humphreys, P., Langevin, P., MacDonald, E.A., Gillett, J., Meaney, B., Shevell, M., Sinclair, D.B., Yager, J. N. Engl. J. Med. (2001) [Pubmed]
  13. The management of thrombosis in the antiphospholipid-antibody syndrome. Khamashta, M.A., Cuadrado, M.J., Mujic, F., Taub, N.A., Hunt, B.J., Hughes, G.R. N. Engl. J. Med. (1995) [Pubmed]
  14. Prevention of thrombosis in patients on hemodialysis by low-dose aspirin. Harter, H.R., Burch, J.W., Majerus, P.W., Stanford, N., Delmez, J.A., Anderson, C.B., Weerts, C.A. N. Engl. J. Med. (1979) [Pubmed]
  15. A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting. Stent Anticoagulation Restenosis Study Investigators. Leon, M.B., Baim, D.S., Popma, J.J., Gordon, P.C., Cutlip, D.E., Ho, K.K., Giambartolomei, A., Diver, D.J., Lasorda, D.M., Williams, D.O., Pocock, S.J., Kuntz, R.E. N. Engl. J. Med. (1998) [Pubmed]
  16. Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis. Cortelazzo, S., Finazzi, G., Ruggeri, M., Vestri, O., Galli, M., Rodeghiero, F., Barbui, T. N. Engl. J. Med. (1995) [Pubmed]
  17. Nephrotoxicity of cyclosporin A after allogeneic marrow transplantation: glomerular thromboses and tubular injury. Shulman, H., Striker, G., Deeg, H.J., Kennedy, M., Storb, R., Thomas, E.D. N. Engl. J. Med. (1981) [Pubmed]
  18. MyosinIIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability. Calaminus, S.D., Auger, J.M., McCarty, O.J., Wakelam, M.J., Machesky, L.M., Watson, S.P. J. Thromb. Haemost. (2007) [Pubmed]
  19. A critical role for extracellular protein disulfide isomerase during thrombus formation in mice. Cho, J., Furie, B.C., Coughlin, S.R., Furie, B. J. Clin. Invest. (2008) [Pubmed]
  20. Serglycin proteoglycan deletion induces defects in platelet aggregation and thrombus formation in mice. Woulfe, D.S., Lilliendahl, J.K., August, S., Rauova, L., Kowalska, M.A., Abrink, M., Pejler, G., White, J.G., Schick, B.P. Blood (2008) [Pubmed]
  21. Endoscopic treatment of esophagogastric variceal bleeding in patients with noncirrhotic extrahepatic portal vein thrombosis: a long-term follow-up study. Spaander, M.C., Darwish Murad, S., van Buuren, H.R., Hansen, B.E., Kuipers, E.J., Janssen, H.L. Gastrointest. Endosc. (2008) [Pubmed]
  22. Risk factors for thrombosis and primary thrombosis prevention in patients with systemic lupus erythematosus with or without antiphospholipid antibodies. Tektonidou, M.G., Laskari, K., Panagiotakos, D.B., Moutsopoulos, H.M. Arthritis Rheum. (2009) [Pubmed]
  23. Images in clinical medicine. Renal-vein thrombosis. Matthews, G.J., Hall, S. N. Engl. J. Med. (2000) [Pubmed]
  24. Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice. Fabre, J.E., Nguyen, M., Latour, A., Keifer, J.A., Audoly, L.P., Coffman, T.M., Koller, B.H. Nat. Med. (1999) [Pubmed]
  25. A potential basis for the thrombotic risks associated with lipoprotein(a). Miles, L.A., Fless, G.M., Levin, E.G., Scanu, A.M., Plow, E.F. Nature (1989) [Pubmed]
  26. Loss of ATP diphosphohydrolase activity with endothelial cell activation. Robson, S.C., Kaczmarek, E., Siegel, J.B., Candinas, D., Koziak, K., Millan, M., Hancock, W.W., Bach, F.H. J. Exp. Med. (1997) [Pubmed]
  27. Impaired arterial neointima formation in mice with disruption of the plasminogen gene. Carmeliet, P., Moons, L., Ploplis, V., Plow, E., Collen, D. J. Clin. Invest. (1997) [Pubmed]
  28. Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Palabrica, T., Lobb, R., Furie, B.C., Aronovitz, M., Benjamin, C., Hsu, Y.M., Sajer, S.A., Furie, B. Nature (1992) [Pubmed]
  29. Letter: Thrombosis of the renal veins and vena cava. Cohen, A.H. JAMA (1976) [Pubmed]
  30. Syndrome of inappropriate secretion of antidiuretic hormone: association with cavernous sinus thrombosis. Feinfeld, D.A., Al-Achkar, G., Lipner, H.I., Chirayil, S.J., Hakim, J., Avram, M.M. JAMA (1978) [Pubmed]
  31. Systemic antithrombotic effects of ADAMTS13. Chauhan, A.K., Motto, D.G., Lamb, C.B., Bergmeier, W., Dockal, M., Plaimauer, B., Scheiflinger, F., Ginsburg, D., Wagner, D.D. J. Exp. Med. (2006) [Pubmed]
  32. Thrombolysis with human extrinsic (tissue-type) plasminogen activator in rabbits with experimental jugular vein thrombosis. Effect of molecular form and dose of activator, age of the thrombus, and route of administration. Collen, D., Stassen, J.M., Verstraete, M. J. Clin. Invest. (1983) [Pubmed]
  33. Recurrent venous thromboembolism in patients with a partial deficiency of protein S. Comp, P.C., Esmon, C.T. N. Engl. J. Med. (1984) [Pubmed]
  34. Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. Angelillo-Scherrer, A., de Frutos, P., Aparicio, C., Melis, E., Savi, P., Lupu, F., Arnout, J., Dewerchin, M., Hoylaerts, M., Herbert, J., Collen, D., Dahlbäck, B., Carmeliet, P. Nat. Med. (2001) [Pubmed]
  35. Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice. Tong, M.H., Jiang, H., Liu, P., Lawson, J.A., Brass, L.F., Song, W.C. Nat. Med. (2005) [Pubmed]
  36. Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction. Bugge, T.H., Flick, M.J., Daugherty, C.C., Degen, J.L. Genes Dev. (1995) [Pubmed]
  37. Bolus fibrinolytic therapy in acute myocardial infarction. Llevadot, J., Giugliano, R.P., Antman, E.M. JAMA (2001) [Pubmed]
  38. Topology of the fibrinolytic system within the mural thrombus of human abdominal aortic aneurysms. Houard, X., Rouzet, F., Touat, Z., Philippe, M., Dominguez, M., Fontaine, V., Sarda-Mantel, L., Meulemans, A., Le Guludec, D., Meilhac, O., Michel, J.B. J. Pathol. (2007) [Pubmed]
  39. Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model. Dubois, C., Panicot-Dubois, L., Gainor, J.F., Furie, B.C., Furie, B. J. Clin. Invest. (2007) [Pubmed]
  40. Role of p38 mitogen-activated protein kinase in antiphospholipid antibody-mediated thrombosis and endothelial cell activation. Vega-Ostertag, M.E., Ferrara, D.E., Romay-Penabad, Z., Liu, X., Taylor, W.R., Colden-Stanfield, M., Pierangeli, S.S. J. Thromb. Haemost. (2007) [Pubmed]
  41. Peripheral tachykinins and the neurokinin receptor NK1 are required for platelet thrombus formation. Jones, S., Tucker, K.L., Sage, T., Kaiser, W.J., Barrett, N.E., Lowry, P.J., Zimmer, A., Hunt, S.P., Emerson, M., Gibbins, J.M. Blood (2008) [Pubmed]
  42. PKCalpha regulates platelet granule secretion and thrombus formation in mice. Konopatskaya, O., Gilio, K., Harper, M.T., Zhao, Y., Cosemans, J.M., Karim, Z.A., Whiteheart, S.W., Molkentin, J.D., Verkade, P., Watson, S.P., Heemskerk, J.W., Poole, A.W. J. Clin. Invest. (2009) [Pubmed]
  43. Adjusted subcutaneous heparin versus warfarin sodium in the long-term treatment of venous thrombosis. Hull, R., Delmore, T., Carter, C., Hirsh, J., Genton, E., Gent, M., Turpie, G., McLaughlin, D. N. Engl. J. Med. (1982) [Pubmed]
  44. Risks of anticoagulant therapy in pregnant women with artificial heart valves. Iturbe-Alessio, I., Fonseca, M.C., Mutchinik, O., Santos, M.A., Zajarías, A., Salazar, E. N. Engl. J. Med. (1986) [Pubmed]
  45. The hazards of scoring the quality of clinical trials for meta-analysis. Jüni, P., Witschi, A., Bloch, R., Egger, M. JAMA (1999) [Pubmed]
  46. Thrombogenicity of total parenteral nutrition solutions: I. Effect on induction of monocyte/macrophage procoagulant activity. Wakefield, A., Cohen, Z., Craig, M., Connolley, P., Jeejeebhoy, K.N., Silverman, R., Levy, G.A. Gastroenterology (1989) [Pubmed]
  47. Protein C deficiency and portal thrombosis in liver transplantation in children. Harper, P.L., Edgar, P.F., Luddington, R.J., Seaman, M.J., Carrell, R.W., Salt, A.T., Barnes, N., Rolles, K., Calne, R.Y. Lancet (1988) [Pubmed]
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