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Kuo, Y.C. et al.

Inhibitory effects of acylated kaempferol glycosides from the leaves of Cinnamomum kotoense on the proliferation of human peripheral blood mononuclear cells.

A new chemical entity, namely kaempferol 3- O-alpha-L-[2-(Z)-p-coumaroyl-4-(E)-p-coumaroyl]rhamnopyranoside (1), and the known kaempferol 3-O-alpha-L-[2,4-di-(E)-p-coumaroyl]rhamnopyranoside (2) have been isolated from the methanolic extract of leaves of Cinnamomum kotoense. Structural elucidation of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. The effects of compounds 1 and 2 on phytohemagglutinin (PHA) stimulated cell proliferation were studied towards human peripheral blood mononuclear cells (PBMC). The results indicated that compounds 1 and 2 suppressed PBMC proliferation induced by PHA with an IC50 value of 5.0 +/- 1.3 and 6.0 +/- 1.5 microM, respectively. Interleukin-2 production in activated PBMC inhibited by compounds 1 and 2 were in a concentration-dependent manner. Therefore, we suggested that compounds 1 and 2 in C. kotoense were likely the growth modulators for PBMC.[1]

References

Inhibitory effects of acylated kaempferol glycosides from the leaves of Cinnamomum kotoense on the proliferation of human peripheral blood mononuclear cells. Kuo, Y.C., Lu, C.K., Huang, L.W., Kuo, Y.H., Chang, C., Hsu, F.L., Lee, T.H. Planta Med. (2005) [Pubmed]

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