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Disease relevance of Cinnamomum


High impact information on Cinnamomum


Biological context of Cinnamomum

  • Cinnamaldehyde is an active compound isolated from the stem bark of Cinnamomum cassia, a traditional oriental medicinal herb, which has been shown to inhibit tumor cell proliferation [7].
  • Taken together, these data suggest that the anti-inflammatory actions of Cinnamomum camphora may be due to the modulation of cytokine, NO and PGE(2) production and oxidative stress, and of the subfractions tested, the EtOAc extract may be further studied to isolate the active anti-inflammatory principles [8].

Anatomical context of Cinnamomum


Associations of Cinnamomum with chemical compounds

  • Cinnamic aldehyde has been identified as the active fungitoxic constituent of cinnamon (Cinnamomum zeylanicum) bark oil [10].
  • Two active compounds that prevent serotonin-induced ulcerogenesis in rats were isolated from Chinese cinnamon (the stem bark of Cinnamomum cassia) and identified as 3-(2-hydroxyphenyl)-propanoic acid and its O-glucoside [11].
  • In vitro activity of the essential oil of Cinnamomum zeylanicum and eugenol in peroxynitrite-induced oxidative processes [12].
  • The biologically active constituent of the Cinnamomum bark was characterized as trans-cinnamaldehyde by spectroscopic analysis [13].
  • Two natural products, farformolide B and sesamin were isolated from Farfugium japonicum and Cinnamomum kanehirae, respectively [14].

Gene context of Cinnamomum


Analytical, diagnostic and therapeutic context of Cinnamomum

  • Porrectin, a new type II ribosome-inactivating protein (RIP), was purified from the seeds of the camphor tree (Cinnamomum porrectum) by affinity chromatography on acid-treated Sepharose 4B [20].
  • The volatile ingredients isolated from a fresh tree of Cinnamomum camphora (camphor tree) and from a tree remain of C. camphora were collected by using headspace techniques and analyzed by means of gas chromatography/mass spectrometry (GC/MS) [21].


  1. Toxicity studies in mice of common spices, Cinnamomum zeylanicum bark and Piper longum fruits. Shah, A.H., Al-Shareef, A.H., Ageel, A.M., Qureshi, S. Plant foods for human nutrition (Dordrecht, Netherlands) (1998) [Pubmed]
  2. Cinnamomin, a type II ribosome-inactivating protein, is a storage protein in the seed of the camphor tree (Cinnamomum camphora). Liu, R.S., Wei, G.Q., Yang, Q., He, W.J., Liu, W.Y. Biochem. J. (2002) [Pubmed]
  3. Pharmacological characterization of cinnamophilin, a novel dual inhibitor of thromboxane synthase and thromboxane A2 receptor. Yu, S.M., Wu, T.S., Teng, C.M. Br. J. Pharmacol. (1994) [Pubmed]
  4. Delayed occurrence of H-ras12V-induced hepatocellular carcinoma with long-term treatment with cinnamaldehydes. Moon, E.Y., Lee, M.R., Wang, A.G., Lee, J.H., Kim, H.C., Kim, H.M., Kim, J.M., Kwon, B.M., Yu, D.Y. Eur. J. Pharmacol. (2006) [Pubmed]
  5. Inhibitory effects of acylated kaempferol glycosides from the leaves of Cinnamomum kotoense on the proliferation of human peripheral blood mononuclear cells. Kuo, Y.C., Lu, C.K., Huang, L.W., Kuo, Y.H., Chang, C., Hsu, F.L., Lee, T.H. Planta Med. (2005) [Pubmed]
  6. Structural studies of an eukaryotic cambialistic superoxide dismutase purified from the mature seeds of camphor tree. Chen, H.Y., Hu, R.G., Wang, B.Z., Chen, W.F., Liu, W.Y., Schröder, W., Frank, P., Ulbrich, N. Arch. Biochem. Biophys. (2002) [Pubmed]
  7. Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells. Ka, H., Park, H.J., Jung, H.J., Choi, J.W., Cho, K.S., Ha, J., Lee, K.T. Cancer Lett. (2003) [Pubmed]
  8. In vitro anti-inflammatory and anti-oxidative effects of Cinnamomum camphora extracts. Lee, H.J., Hyun, E.A., Yoon, W.J., Kim, B.H., Rhee, M.H., Kang, H.K., Cho, J.Y., Yoo, E.S. Journal of ethnopharmacology. (2006) [Pubmed]
  9. Inhibitory effects of flavonol glycosides from Cinnamomum osmophloeum on inflammatory mediators in LPS/IFN-gamma-activated murine macrophages. Fang, S.H., Rao, Y.K., Tzeng, Y.M. Bioorg. Med. Chem. (2005) [Pubmed]
  10. Cinnamon bark oil, a potent fungitoxicant against fungi causing respiratory tract mycoses. Singh, H.B., Srivastava, M., Singh, A.B., Srivastava, A.K. Allergy (1995) [Pubmed]
  11. Antiulcerogenic compounds isolated from Chinese cinnamon. Tanaka, S., Yoon, Y.H., Fukui, H., Tabata, M., Akira, T., Okano, K., Iwai, M., Iga, Y., Yokoyama, K. Planta Med. (1989) [Pubmed]
  12. In vitro activity of the essential oil of Cinnamomum zeylanicum and eugenol in peroxynitrite-induced oxidative processes. Chericoni, S., Prieto, J.M., Iacopini, P., Cioni, P., Morelli, I. J. Agric. Food Chem. (2005) [Pubmed]
  13. Insecticidal and fumigant activities of Cinnamomum cassia bark-derived materials against Mechoris ursulus (Coleoptera: attelabidae). Park, I.K., Lee, H.S., Lee, S.G., Park, J.D., Ahn, Y.J. J. Agric. Food Chem. (2000) [Pubmed]
  14. NMR spectroscopic, mass spectroscopic, X-ray crystallographic, and theoretical studies of molecular mechanics of natural products: farformolide B and sesamin. Hsieh, T.J., Lu, L.H., Su, C.C. Biophys. Chem. (2005) [Pubmed]
  15. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. Subehan, n.u.l.l., Usia, T., Iwata, H., Kadota, S., Tezuka, Y. Journal of ethnopharmacology. (2006) [Pubmed]
  16. Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. Hong, C.H., Hur, S.K., Oh, O.J., Kim, S.S., Nam, K.A., Lee, S.K. Journal of ethnopharmacology. (2002) [Pubmed]
  17. Cinnamophilin, a novel thromboxane A2 receptor antagonist, isolated from Cinnamomum philippinense. Yu, S.M., Ko, F.N., Wu, T.S., Lee, J.Y., Teng, C.M. Eur. J. Pharmacol. (1994) [Pubmed]
  18. Phenolic constituents in the fruits of Cinnamomum zeylanicum and their antioxidant activity. Jayaprakasha, G.K., Ohnishi-Kameyama, M., Ono, H., Yoshida, M., Jaganmohan Rao, L. J. Agric. Food Chem. (2006) [Pubmed]
  19. Impact of elevated CO2 concentration under three soil water levels on growth of Cinnamomum camphora. Zhao, X.Z., Wang, G.X., Shen, Z.X., Zhang, H., Qiu, M.Q. Journal of Zhejiang University. Science. B. (2006) [Pubmed]
  20. Purification of a new ribosome-inactivating protein from the seeds of Cinnamomum porrectum and characterization of the RNA N-glycosidase activity of the toxic protein. Li, X.D., Liu, W.Y., Niu, C.L. Biol. Chem. (1996) [Pubmed]
  21. Headspace constituents of the tree remain of Cinnamomum camphora. Miyazawa, M., Hashimoto, Y., Taniguchi, Y., Kubota, K. Natural product letters. (2001) [Pubmed]
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