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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Lassa fever encephalopathy: clinical and laboratory findings.

Clinical and laboratory findings are reported in nine patients who developed acute encephalopathy during the course of Lassa fever. The encephalopathy manifested 3-17 days after disease onset with confusion, followed rapidly by tremor (seven patients), grand mal convulsions (seven), abnormal posturing (three) and coma (eight); focal neurological signs and evidence of raised intracranial pressure were not seen. Eight patients died, most commonly from respiratory arrest following a protracted fit. Development of encephalopathy did not correlate with the presence of virus in cerebrospinal fluid (CSF), nor with virus antibodies in CSF and/or serum; thus, neither direct cytopathic nor immune-mediated mechanisms seem to be involved in its pathogenesis.[1]


  1. Lassa fever encephalopathy: clinical and laboratory findings. Cummins, D., Bennett, D., Fisher-Hoch, S.P., Farrar, B., Machin, S.J., McCormick, J.B. The Journal of tropical medicine and hygiene. (1992) [Pubmed]
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