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MeSH Review

Lassa Fever

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Disease relevance of Lassa Fever


High impact information on Lassa Fever


Chemical compound and disease context of Lassa Fever


Gene context of Lassa Fever

  • These data indicate that acute nonfatal Lassa fever is associated with high levels of circulating IL-8 and IP-10 and that low levels or absence of these mediators correlates with a poor outcome [8].
  • The large (L) RNA segment of Lassa fever virus (LAS) encodes a putative RNA-dependent RNA polymerase (RdRp or L protein) [11].
  • The recombinant ELISA was able to clearly distinguish sera from human cases of Lassa fever against a panel of known negative sera of African origin [12].
  • Handling patients with suspected Lassa fever entering Great Britain [13].
  • OBJECTIVES: Lassa fever virus (LAS) is transmitted to man by rodent carriers and is fatal in a third of untreated cases [14].

Analytical, diagnostic and therapeutic context of Lassa Fever

  • These studies in a realistic primate model suggest that the antigen detection ELISA or the IgM capture ELISA described, in which beta-propiolactone-inactivated sera are used, should be useful for the rapid diagnosis of human Lassa fever [15].
  • 5-8% of 434 sera collected in Lassa village, Nigeria, in August 1970 were positive by neutralization test for Lassa fever (LF) virus [16].
  • Regarding future applications to diagnostic assays, the recombinant glycoprotein proved to be an effective substitute for Lassa virus-infected mammalian cells in IFAs and it was able to distinguish sera from several human cases of Lassa fever, against a panel of known negative sera of African origin, in an enzyme immunoassay (EIA) [17].


  1. Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus. Cao, W., Henry, M.D., Borrow, P., Yamada, H., Elder, J.H., Ravkov, E.V., Nichol, S.T., Compans, R.W., Campbell, K.P., Oldstone, M.B. Science (1998) [Pubmed]
  2. Protection of rhesus monkeys from fatal Lassa fever by vaccination with a recombinant vaccinia virus containing the Lassa virus glycoprotein gene. Fisher-Hoch, S.P., McCormick, J.B., Auperin, D., Brown, B.G., Castor, M., Perez, G., Ruo, S., Conaty, A., Brammer, L., Bauer, S. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  3. Lassa fever. Effective therapy with ribavirin. McCormick, J.B., King, I.J., Webb, P.A., Scribner, C.L., Craven, R.B., Johnson, K.M., Elliott, L.H., Belmont-Williams, R. N. Engl. J. Med. (1986) [Pubmed]
  4. Acute sensorineural deafness in Lassa fever. Cummins, D., McCormick, J.B., Bennett, D., Samba, J.A., Farrar, B., Machin, S.J., Fisher-Hoch, S.P. JAMA (1990) [Pubmed]
  5. Identification of Lassa fever virus infection with recombinant nucleocapsid protein antigen. Lloyd, G., Barber, G.N., Clegg, J.C., Kelly, P. Lancet (1989) [Pubmed]
  6. Inhibition of different Lassa virus strains by alpha and gamma interferons and comparison with a less pathogenic arenavirus. Asper, M., Sternsdorf, T., Hass, M., Drosten, C., Rhode, A., Schmitz, H., Günther, S. J. Virol. (2004) [Pubmed]
  7. Genetic diversity among Lassa virus strains. Bowen, M.D., Rollin, P.E., Ksiazek, T.G., Hustad, H.L., Bausch, D.G., Demby, A.H., Bajani, M.D., Peters, C.J., Nichol, S.T. J. Virol. (2000) [Pubmed]
  8. Low levels of interleukin-8 and interferon-inducible protein-10 in serum are associated with fatal infections in acute Lassa fever. Mahanty, S., Bausch, D.G., Thomas, R.L., Goba, A., Bah, A., Peters, C.J., Rollin, P.E. J. Infect. Dis. (2001) [Pubmed]
  9. Plasma from patients with severe Lassa fever profoundly modulates f-met-leu-phe induced superoxide generation in neutrophils. Roberts, P.J., Cummins, D., Bainton, A.L., Walshe, K.J., Fisher-Hoch, S.P., McCormick, J.B., Gribben, J.G., Machin, S.J., Linch, D.C. Br. J. Haematol. (1989) [Pubmed]
  10. Journal of Infection Control Nursing. Nursing the isolated patient: Lassa fever. Bowell, E. Nursing times. (1986) [Pubmed]
  11. The Lassa fever virus L gene: nucleotide sequence, comparison, and precipitation of a predicted 250 kDa protein with monospecific antiserum. Lukashevich, I.S., Djavani, M., Shapiro, K., Sanchez, A., Ravkov, E., Nichol, S.T., Salvato, M.S. J. Gen. Virol. (1997) [Pubmed]
  12. Expression of the Lassa virus nucleocapsid protein in insect cells infected with a recombinant baculovirus: application to diagnostic assays for Lassa virus infection. Barber, G.N., Clegg, J.C., Lloyd, G. J. Gen. Virol. (1990) [Pubmed]
  13. Handling patients with suspected Lassa fever entering Great Britain. Woodruff, A.W. Bull. World Health Organ. (1975) [Pubmed]
  14. Mucosal immunization with Salmonella typhimurium expressing Lassa virus nucleocapsid protein cross-protects mice from lethal challenge with lymphocytic choriomeningitis virus. Djavani, M., Yin, C., Lukashevich, I.S., Rodas, J., Rai, S.K., Salvato, M.S. J. Hum. Virol. (2001) [Pubmed]
  15. Detection of Lassa virus antigens and Lassa virus-specific immunoglobulins G and M by enzyme-linked immunosorbent assay. Niklasson, B.S., Jahrling, P.B., Peters, C.J. J. Clin. Microbiol. (1984) [Pubmed]
  16. A neutralization test survey for Lassa Fever activity in Lassa, Nigeria. Arnold, R.B., Gary, G.W. Trans. R. Soc. Trop. Med. Hyg. (1977) [Pubmed]
  17. Baculovirus expression of the glycoprotein gene of Lassa virus and characterization of the recombinant protein. Hummel, K.B., Martin, M.L., Auperin, D.D. Virus Res. (1992) [Pubmed]
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