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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Epilepsy, Tonic-Clonic

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Disease relevance of Epilepsy, Tonic-Clonic


High impact information on Epilepsy, Tonic-Clonic


Chemical compound and disease context of Epilepsy, Tonic-Clonic


Biological context of Epilepsy, Tonic-Clonic

  • The encephalopathy manifested 3-17 days after disease onset with confusion, followed rapidly by tremor (seven patients), grand mal convulsions (seven), abnormal posturing (three) and coma (eight); focal neurological signs and evidence of raised intracranial pressure were not seen [16].

Anatomical context of Epilepsy, Tonic-Clonic

  • The present experiment examined this hypothesis by comparing sleep-waking state percentages and the number of after-discharge-eliciting stimulations required to induce generalized tonic-clonic convulsions with the amygdala kindling model of epilepsy in 3 groups of cats (n = 5 each) [17].

Gene context of Epilepsy, Tonic-Clonic


Analytical, diagnostic and therapeutic context of Epilepsy, Tonic-Clonic


  1. Cerebral transmural angiitis and ruptured aneurysm: a complication of systemic lupus erythematosus. Kelley, R.E., Stokes, N., Reyes, P., Harik, S.I. Arch. Neurol. (1980) [Pubmed]
  2. Pentylenetetrazol-induced seizures decrease gamma-aminobutyric acid-mediated recurrent inhibition and enhance adenosine-mediated depression. Psarropoulou, C., Matsokis, N., Angelatou, F., Kostopoulos, G. Epilepsia (1994) [Pubmed]
  3. Convulsant activity of pyridoxal sulphate and phosphonoethyl pyridoxal: antagonism by GABA and its synthetic analogues. Ebadi, M., Metzler, D.E., Christenson, W.R. Neuropharmacology (1983) [Pubmed]
  4. Treatment of epilepsy with clonazepam and its effect on other anticonvulsants. Nanda, R.N., Johnson, R.H., Keogh, H.J., Lambie, D.G., Melville, I.D. J. Neurol. Neurosurg. Psychiatr. (1977) [Pubmed]
  5. Chromosomal mapping of genes for epilepsy in NER: a rat strain with tonic-clonic seizures. Maihara, T., Noda, A., Yamazoe, H., Voigt, B., Kitada, K., Serikawa, T. Epilepsia (2000) [Pubmed]
  6. Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase. Hogema, B.M., Gupta, M., Senephansiri, H., Burlingame, T.G., Taylor, M., Jakobs, C., Schutgens, R.B., Froestl, W., Snead, O.C., Diaz-Arrastia, R., Bottiglieri, T., Grompe, M., Gibson, K.M. Nat. Genet. (2001) [Pubmed]
  7. Eyelid twitching seizures and generalized tonic-clonic convulsions: a syndrome of idiopathic generalized epilepsy. Miller, J.W., Ferrendelli, J.A. Ann. Neurol. (1990) [Pubmed]
  8. Changes in plasma catecholamines after tonic-clonic seizures. Simon, R.P., Aminoff, M.J., Benowitz, N.L. Neurology (1984) [Pubmed]
  9. Characterization of seizure-induced cysteinyl-leukotriene formation in brain tissue of convulsion-prone gerbils. Simmet, T., Seregi, A., Hertting, G. J. Neurochem. (1988) [Pubmed]
  10. Stimulation of free fatty acid and diacylglycerol accumulation in cerebrum and cerebellum during bicuculline-induced status epilepticus. Effect of pretreatment with alpha-methyl-p-tyrosine and p-chlorophenylalamine. Rodriguez de Turco, E.B., Morelli de Liberti, S., Bazan, N.G. J. Neurochem. (1983) [Pubmed]
  11. Effect of vigabatrin on epilepsy in mentally retarded patients: a 7-month follow-up study. Matilainen, R., Pitkänen, A., Ruutiainen, T., Mervaala, E., Sarlund, H., Riekkinen, P. Neurology (1988) [Pubmed]
  12. Tolerance to the anti-pentylenetetrazole effects of diazepam in the mouse. File, S.E. Psychopharmacology (Berl.) (1983) [Pubmed]
  13. Effects of microdialysis on brain metabolism in normal and seizure states. Chastain, J.E., Samson, F., Nelson, S.R., Pazdernik, T.L. Neuroscience (1990) [Pubmed]
  14. Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats. Morrisett, R.A., Jope, R.S., Snead, O.C. Exp. Neurol. (1987) [Pubmed]
  15. Nonmuscarinic neurotoxicity of oxotremorine. Witkin, J.M., Alvarado-Garcia, R., Lee, M.A., Witkin, K.M. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  16. Lassa fever encephalopathy: clinical and laboratory findings. Cummins, D., Bennett, D., Fisher-Hoch, S.P., Farrar, B., Machin, S.J., McCormick, J.B. The Journal of tropical medicine and hygiene. (1992) [Pubmed]
  17. Sleep disruption with basal forebrain lesions decreases latency to amygdala kindling in cats. Shouse, M.N., Sterman, M.B., Hauri, P.J., Belsito, O. Electroencephalography and clinical neurophysiology. (1984) [Pubmed]
  18. Platelet-derived growth factor B-chain homodimer suppressing a convulsion of epilepsy model mouse El. Masuda, Y., Miura, N., Kawarada, Y., Kawagoe, M., Shimizu, T., Sugiyama, T., Hishikawa, Y. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  19. Tonic-clonic seizures induce division of neuronal progenitor cells with concomitant changes in expression of neurotrophic factors in the brain of pilocarpine-treated mice. Hagihara, H., Hara, M., Tsunekawa, K., Nakagawa, Y., Sawada, M., Nakano, K. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  20. In vivo modification of GABAA receptor with a high dose of pyridoxal phosphate induces tonic-clonic convulsion in immature mice. Ishioka, N., Sato, J., Nakamura, J., Ohkubo, T., Takeda, A., Kurioka, S. Neurochem. Int. (1995) [Pubmed]
  21. Selective susceptibility to inhibitors of GABA synthesis and antagonists of GABA(A) receptor in rats with genetic absence epilepsy. Vergnes, M., Boehrer, A., Reibel, S., Simler, S., Marescaux, C. Exp. Neurol. (2000) [Pubmed]
  22. Antiepileptic effects of acidic fibroblast growth factor examined in kainic acid-mediated seizures in the rat. Cuevas, P., Giménez-Gallego, G. Neurosci. Lett. (1996) [Pubmed]
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