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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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BAF complex is closely related to and interacts with NF1/CTF and RNA polymerase II in gene transcriptional activation.

Brg- or hBrm-associated factor ( BAF) complexes, a chromatin-remodeling complex family of mammalian cells, facilitate transcriptional activity by remodeling nucleosome structure. Brg1 is the core subunit of Brg-associated factor complexes. In the present study, we investigated the spatial relationship between Brg1 and nuclear factor 1 ( NF1/CTF) and RNA polymerase II (RNAP II) upon gene transcriptional activation in vivo by employing immuno-gold labeling. The data showed that Brg1 was closely co-localized with NF1/CTF and RNAP II in HeLa cells. Moreover, the co-immunoprecipitation assay further revealed that Brg1 can be isolated together with NF1/CTF and RNAP II in the ConA-stimulated, but not the resting, T lymphocyte. The combined results suggested that BAF complexes can interact with NF1/CTF and RNAP II, and this interaction is closely dependent on the activation of gene transcription.[1]

References

  1. BAF complex is closely related to and interacts with NF1/CTF and RNA polymerase II in gene transcriptional activation. Zhao, L.H., Ba, X.Q., Wang, X.G., Zhu, X.J., Wang, L., Zeng, X.L. Acta Biochim. Biophys. Sin. (Shanghai) (2005) [Pubmed]
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