Gene Review:
SMARCA4 - SWI/SNF related, matrix associated, actin...
Homo sapiens
Synonyms:
ATP-dependent helicase SMARCA4, BAF190, BAF190A, BRG1, BRG1-associated factor 190A, ...
- Genetic and epigenetic screening for gene alterations of the chromatin-remodeling factor, SMARCA4/BRG1, in lung tumors. Medina, P.P., Carretero, J., Fraga, M.F., Esteller, M., Sidransky, D., Sanchez-Cespedes, M. Genes Chromosomes Cancer (2004)
- BRG1 controls the activity of the retinoblastoma protein via regulation of p21CIP1/WAF1/SDI. Kang, H., Cui, K., Zhao, K. Mol. Cell. Biol. (2004)
- Human SWI-SNF component BRG1 represses transcription of the c-fos gene. Murphy, D.J., Hardy, S., Engel, D.A. Mol. Cell. Biol. (1999)
- Reconstitution of glucocorticoid receptor-dependent transcription in vivo. Trotter, K.W., Archer, T.K. Mol. Cell. Biol. (2004)
- Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex. Otsuki, T., Furukawa, Y., Ikeda, K., Endo, H., Yamashita, T., Shinohara, A., Iwamatsu, A., Ozawa, K., Liu, J.M. Hum. Mol. Genet. (2001)
- BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Bochar, D.A., Wang, L., Beniya, H., Kinev, A., Xue, Y., Lane, W.S., Wang, W., Kashanchi, F., Shiekhattar, R. Cell (2000)
- The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Dunaief, J.L., Strober, B.E., Guha, S., Khavari, P.A., Alin, K., Luban, J., Begemann, M., Crabtree, G.R., Goff, S.P. Cell (1994)
- BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription. Khavari, P.A., Peterson, C.L., Tamkun, J.W., Mendel, D.B., Crabtree, G.R. Nature (1993)
- Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease. Bilodeau, S., Vallette-Kasic, S., Gauthier, Y., Figarella-Branger, D., Brue, T., Berthelet, F., Lacroix, A., Batista, D., Stratakis, C., Hanson, J., Meij, B., Drouin, J. Genes Dev. (2006)
- SNF2beta-BRG1 is essential for the viability of F9 murine embryonal carcinoma cells. Sumi-Ichinose, C., Ichinose, H., Metzger, D., Chambon, P. Mol. Cell. Biol. (1997)
- Transcriptional targets of the chromatin-remodelling factor SMARCA4/BRG1 in lung cancer cells. Medina, P.P., Carretero, J., Ballestar, E., Angulo, B., Lopez-Rios, F., Esteller, M., Sanchez-Cespedes, M. Hum. Mol. Genet. (2005)
- Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. Wang, W., Côté, J., Xue, Y., Zhou, S., Khavari, P.A., Biggar, S.R., Muchardt, C., Kalpana, G.V., Goff, S.P., Yaniv, M., Workman, J.L., Crabtree, G.R. EMBO J. (1996)
- REST repression of neuronal genes requires components of the hSWI.SNF complex. Battaglioli, E., Andrés, M.E., Rose, D.W., Chenoweth, J.G., Rosenfeld, M.G., Anderson, M.E., Mandel, G. J. Biol. Chem. (2002)
- Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha. Nielsen, A.L., Sanchez, C., Ichinose, H., Cerviño, M., Lerouge, T., Chambon, P., Losson, R. EMBO J. (2002)
- LIM-only protein, CRP2, switched on smooth muscle gene activity in adult cardiac myocytes. Chang, D.F., Belaguli, N.S., Chang, J., Schwartz, R.J. Proc. Natl. Acad. Sci. U.S.A. (2007)
- BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines. Wong, A.K., Shanahan, F., Chen, Y., Lian, L., Ha, P., Hendricks, K., Ghaffari, S., Iliev, D., Penn, B., Woodland, A.M., Smith, R., Salada, G., Carillo, A., Laity, K., Gupte, J., Swedlund, B., Tavtigian, S.V., Teng, D.H., Lees, E. Cancer Res. (2000)
- BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation. DiRenzo, J., Shang, Y., Phelan, M., Sif, S., Myers, M., Kingston, R., Brown, M. Mol. Cell. Biol. (2000)
- Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2. Ichinose, H., Garnier, J.M., Chambon, P., Losson, R. Gene (1997)
- Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation. Gwack, Y., Baek, H.J., Nakamura, H., Lee, S.H., Meisterernst, M., Roeder, R.G., Jung, J.U. Mol. Cell. Biol. (2003)
- BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. Hsiao, P.W., Fryer, C.J., Trotter, K.W., Wang, W., Archer, T.K. Mol. Cell. Biol. (2003)
- EVI1 promotes cell proliferation by interacting with BRG1 and blocking the repression of BRG1 on E2F1 activity. Chi, Y., Senyuk, V., Chakraborty, S., Nucifora, G. J. Biol. Chem. (2003)
- LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest. Marignani, P.A., Kanai, F., Carpenter, C.L. J. Biol. Chem. (2001)
- Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes. Huang, M., Qian, F., Hu, Y., Ang, C., Li, Z., Wen, Z. Nat. Cell Biol. (2002)
- Multiple interactions between BRG1 and MHC class II promoter binding proteins. Mudhasani, R., Fontes, J.D. Mol. Immunol. (2005)
- BAF complex is closely related to and interacts with NF1/CTF and RNA polymerase II in gene transcriptional activation. Zhao, L.H., Ba, X.Q., Wang, X.G., Zhu, X.J., Wang, L., Zeng, X.L. Acta Biochim. Biophys. Sin. (Shanghai) (2005)
- Interferon-gamma-induced chromatin remodeling at the CIITA locus is BRG1 dependent. Pattenden, S.G., Klose, R., Karaskov, E., Bremner, R. EMBO J. (2002)
- SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription. Lee, D., Kim, J.W., Seo, T., Hwang, S.G., Choi, E.J., Choe, J. J. Biol. Chem. (2002)
- Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1 gene. Giraud, S., Hurlstone, A., Avril, S., Coqueret, O. Oncogene (2004)
- Apical role for BRG1 in cytokine-induced promoter assembly. Ni, Z., Karaskov, E., Yu, T., Callaghan, S.M., Der, S., Park, D.S., Xu, Z., Pattenden, S.G., Bremner, R. Proc. Natl. Acad. Sci. U.S.A. (2005)
- The activity of p53 is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexes. Xu, Y., Zhang, J., Chen, X. J. Biol. Chem. (2007)
- Role for BRG1 in cell cycle control and tumor suppression. Hendricks, K.B., Shanahan, F., Lees, E. Mol. Cell. Biol. (2004)