- Chronic beta-adrenergic receptor stimulation enhances the expression of G-Protein coupled receptor kinases, GRK2 and GRK5, in both the heart and peripheral lymphocytes. Oyama, N., Urasawa, K., Kaneta, S., Sakai, H., Saito, T., Takagi, C., Yoshida, I., Kitabatake, A., Tsutsui, H. Circ. J. (2005)