The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Gpr1  -  G protein-coupled receptor 1

Rattus norvegicus

Synonyms: G-protein coupled receptor 1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Gpr1


Psychiatry related information on Gpr1


High impact information on Gpr1

  • ADP mediates platelet aggregation through its action on two G-protein-coupled receptor subtypes [7].
  • Here we show that DCC interacts with the membrane-associated adenosine A2b receptor, a G-protein-coupled receptor that induces cAMP accumulation on binding adenosine [8].
  • Our findings provide the first evidence for a direct interaction between a steroid hormone and a G-protein-coupled receptor and define a new level of crosstalk between the peptide- and steroid-hormone signalling pathways [9].
  • Thrombin is a coagulation protease that activates platelets, leukocytes, endothelial and mesenchymal cells at sites of vascular injury, acting partly through an unusual proteolytically activated G-protein-coupled receptor [10].
  • Cloning of a KSHV genome fragment revealed the presence of an open reading frame encoding a putative G-protein-coupled receptor that is homologous to a G-protein-coupled receptor encoded by herpesvirus Saimiri and to human interleukin-8 receptors [2].

Chemical compound and disease context of Gpr1


Biological context of Gpr1


Anatomical context of Gpr1


Associations of Gpr1 with chemical compounds


Physical interactions of Gpr1


Regulatory relationships of Gpr1


Other interactions of Gpr1

  • Conditional expression of RasN17 (a dominant-negative mutant) in Rat-1 cells inhibited activation of MAP kinases by EGF and also LPA, the first time a defined G-protein-coupled receptor mitogen has been shown to require Ras to exert its effects [38].
  • Using a pharmacological approach, we report for the first time that compounds SB202190 and SB203580 were able to directly and selectively interact with a G-protein-coupled receptor, namely the cholecystokinin receptor subtype CCK1, but not with the CCK2 receptor [39].
  • Taken together, the data elucidate a G-protein-coupled receptor signaling pathway for ETB receptor-mediated NO production and call attention to the absolute requirement for heterotrimeric G-protein betagamma subunits in this cascade [40].
  • The ETA receptor is a seven-transmembrane G-protein-coupled receptor whose precise subcellular localization in cardiac muscle is unknown [41].
  • Taken together, our results suggest that IRS-1 may serve as a converging target in the signaling pathways stimulated by receptors that belong to different families, such as the gastrin/CCKB G protein-coupled receptor and the insulin receptor [42].

Analytical, diagnostic and therapeutic context of Gpr1


  1. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Matsuda, L.A., Lolait, S.J., Brownstein, M.J., Young, A.C., Bonner, T.I. Nature (1990) [Pubmed]
  2. Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Arvanitakis, L., Geras-Raaka, E., Varma, A., Gershengorn, M.C., Cesarman, E. Nature (1997) [Pubmed]
  3. Broad-spectrum G protein-coupled receptor antagonist, [D-Arg1,D-Trp5,7,9,Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer. Guha, S., Eibl, G., Kisfalvi, K., Fan, R.S., Burdick, M., Reber, H., Hines, O.J., Strieter, R., Rozengurt, E. Cancer Res. (2005) [Pubmed]
  4. Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways. Sah, V.P., Hoshijima, M., Chien, K.R., Brown, J.H. J. Biol. Chem. (1996) [Pubmed]
  5. Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells. Akbar, G.K., Dasari, V.R., Webb, T.E., Ayyanathan, K., Pillarisetti, K., Sandhu, A.K., Athwal, R.S., Daniel, J.L., Ashby, B., Barnard, E.A., Kunapuli, S.P. J. Biol. Chem. (1996) [Pubmed]
  6. Neuroanatomical distribution of CXCR4 in adult rat brain and its localization in cholinergic and dopaminergic neurons. Banisadr, G., Fontanges, P., Haour, F., Kitabgi, P., Rostène, W., Mélik Parsadaniantz, S. Eur. J. Neurosci. (2002) [Pubmed]
  7. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Hollopeter, G., Jantzen, H.M., Vincent, D., Li, G., England, L., Ramakrishnan, V., Yang, R.B., Nurden, P., Nurden, A., Julius, D., Conley, P.B. Nature (2001) [Pubmed]
  8. Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor. Corset, V., Nguyen-Ba-Charvet, K.T., Forcet, C., Moyse, E., Chédotal, A., Mehlen, P. Nature (2000) [Pubmed]
  9. Inhibition of oxytocin receptor function by direct binding of progesterone. Grazzini, E., Guillon, G., Mouillac, B., Zingg, H.H. Nature (1998) [Pubmed]
  10. Protease-activated receptor 3 is a second thrombin receptor in humans. Ishihara, H., Connolly, A.J., Zeng, D., Kahn, M.L., Zheng, Y.W., Timmons, C., Tram, T., Coughlin, S.R. Nature (1997) [Pubmed]
  11. The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. Sadoshima, J., Izumo, S. EMBO J. (1996) [Pubmed]
  12. Purification and characterization of an allergy-induced melanogenic stimulating factor in brownish guinea pig skin. Imokawa, G., Higuchi, K., Yada, Y. J. Biol. Chem. (1998) [Pubmed]
  13. Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse delta opioid receptor in Rat-1 fibroblasts: effects of receptor expression levels and comparisons with G-protein activation. Burt, A.R., Carr, I.C., Mullaney, I., Anderson, N.G., Milligan, G. Biochem. J. (1996) [Pubmed]
  14. Cytoskeleton-related trafficking of the EAAC1 glutamate transporter after activation of the G(q/11)-coupled neurotensin receptor NTS1. Najimi, M., Maloteaux, J.M., Hermans, E. FEBS Lett. (2002) [Pubmed]
  15. Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet beta-cells: mediation by PLC and L-type Ca2+ channel and link to insulin release. Fujiwara, K., Maekawa, F., Yada, T. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  16. Analysis of ligand-stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies. Pollok-Kopp, B., Schwarze, K., Baradari, V.K., Oppermann, M. J. Biol. Chem. (2003) [Pubmed]
  17. Lysophosphatidic acid induces neointima formation through PPARgamma activation. Zhang, C., Baker, D.L., Yasuda, S., Makarova, N., Balazs, L., Johnson, L.R., Marathe, G.K., McIntyre, T.M., Xu, Y., Prestwich, G.D., Byun, H.S., Bittman, R., Tigyi, G. J. Exp. Med. (2004) [Pubmed]
  18. alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor. Krasnoperov, V.G., Bittner, M.A., Beavis, R., Kuang, Y., Salnikow, K.V., Chepurny, O.G., Little, A.R., Plotnikov, A.N., Wu, D., Holz, R.W., Petrenko, A.G. Neuron (1997) [Pubmed]
  19. Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. Juhaszova, M., Zorov, D.B., Kim, S.H., Pepe, S., Fu, Q., Fishbein, K.W., Ziman, B.D., Wang, S., Ytrehus, K., Antos, C.L., Olson, E.N., Sollott, S.J. J. Clin. Invest. (2004) [Pubmed]
  20. Serum-induced membrane depolarization in quiescent fibroblasts: activation of a chloride conductance through the G protein-coupled LPA receptor. Postma, F.R., Jalink, K., Hengeveld, T., Bot, A.G., Alblas, J., de Jonge, H.R., Moolenaar, W.H. EMBO J. (1996) [Pubmed]
  21. G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors. Lu, W.Y., Xiong, Z.G., Lei, S., Orser, B.A., Dudek, E., Browning, M.D., MacDonald, J.F. Nat. Neurosci. (1999) [Pubmed]
  22. Nerve growth cone guidance mediated by G protein-coupled receptors. Xiang, Y., Li, Y., Zhang, Z., Cui, K., Wang, S., Yuan, X.B., Wu, C.P., Poo, M.M., Duan, S. Nat. Neurosci. (2002) [Pubmed]
  23. G-protein coupled and tyrosine kinase receptors: evidence that activation of the insulin-like growth factor I receptor is required for thrombin-induced mitogenesis of rat aortic smooth muscle cells. Delafontaine, P., Anwar, A., Lou, H., Ku, L. J. Clin. Invest. (1996) [Pubmed]
  24. Thrombin receptor activation elicits rapid protein tyrosine phosphorylation and stimulation of the raf-1/MAP kinase pathway preceding delayed mitogenesis in cultured rat aortic smooth muscle cells: evidence for an obligate autocrine mechanism promoting cell proliferation induced by G-protein-coupled receptor agonist. Molloy, C.J., Pawlowski, J.E., Taylor, D.S., Turner, C.E., Weber, H., Peluso, M. J. Clin. Invest. (1996) [Pubmed]
  25. Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src. Ishida, T., Ishida, M., Suero, J., Takahashi, M., Berk, B.C. J. Clin. Invest. (1999) [Pubmed]
  26. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Bandell, M., Story, G.M., Hwang, S.W., Viswanath, V., Eid, S.R., Petrus, M.J., Earley, T.J., Patapoutian, A. Neuron (2004) [Pubmed]
  27. A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy. Senbonmatsu, T., Saito, T., Landon, E.J., Watanabe, O., Price, E., Roberts, R.L., Imboden, H., Fitzgerald, T.G., Gaffney, F.A., Inagami, T. EMBO J. (2003) [Pubmed]
  28. Site-directed mutagenesis of the m3 muscarinic receptor: identification of a series of threonine and tyrosine residues involved in agonist but not antagonist binding. Wess, J., Gdula, D., Brann, M.R. EMBO J. (1991) [Pubmed]
  29. Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo. Mantyh, P.W., Allen, C.J., Ghilardi, J.R., Rogers, S.D., Mantyh, C.R., Liu, H., Basbaum, A.I., Vigna, S.R., Maggio, J.E. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  30. An EP2 receptor-selective prostaglandin E2 agonist induces bone healing. Paralkar, V.M., Borovecki, F., Ke, H.Z., Cameron, K.O., Lefker, B., Grasser, W.A., Owen, T.A., Li, M., DaSilva-Jardine, P., Zhou, M., Dunn, R.L., Dumont, F., Korsmeyer, R., Krasney, P., Brown, T.A., Plowchalk, D., Vukicevic, S., Thompson, D.D. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  31. Somatostatin receptor subtype 1 (sst(1)) regulates intracellular 3',5'-cyclic adenosine monophosphate accumulation in rat embryonic cortical neurons: evidence with L-797,591, an sst(1)-subtype-selective nonpeptidyl agonist. Blake, A.D. Neuropharmacology (2001) [Pubmed]
  32. Receptor selectivity of the cloned opossum G protein-coupled receptor kinase 2 (GRK2) in intact opossum kidney cells: role in desensitization of endogenous alpha2C-adrenergic but not serotonin 1B receptors. Lembo, P.M., Ghahremani, M.H., Albert, P.R. Mol. Endocrinol. (1999) [Pubmed]
  33. Differential regulation of extracellular signal-regulated protein kinase 1 and Jun N-terminal kinase 1 by Ca2+ and protein kinase C in endothelin-stimulated Rat-1 cells. Cadwallader, K., Beltman, J., McCormick, F., Cook, S. Biochem. J. (1997) [Pubmed]
  34. Role of c-Jun NH2-terminal kinase in G-protein-coupled receptor agonist-induced cardiac plasminogen activator inhibitor-1 expression. Omura, T., Yoshiyama, M., Matsumoto, R., Kusuyama, T., Enomoto, S., Nishiya, D., Izumi, Y., Kim, S., Ichijo, H., Motojima, M., Akioka, K., Iwao, H., Takeuchi, K., Yoshikawa, J. J. Mol. Cell. Cardiol. (2005) [Pubmed]
  35. Heterologous desensitization of the glucagon-like peptide-1 receptor by phorbol esters requires phosphorylation of the cytoplasmic tail at four different sites. Widmann, C., Dolci, W., Thorens, B. J. Biol. Chem. (1996) [Pubmed]
  36. Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes. Wang, S., Hashemi, T., Fried, S., Clemmons, A.L., Hawes, B.E. Biochemistry (1998) [Pubmed]
  37. Creatine kinase, an ATP-generating enzyme, is required for thrombin receptor signaling to the cytoskeleton. Mahajan, V.B., Pai, K.S., Lau, A., Cunningham, D.D. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  38. RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. Cook, S.J., Rubinfeld, B., Albert, I., McCormick, F. EMBO J. (1993) [Pubmed]
  39. Cross-interactions of two p38 mitogen-activated protein (MAP) kinase inhibitors and two cholecystokinin (CCK) receptor antagonists with the CCK1 receptor and p38 MAP kinase. Morel, C., Ibarz, G., Oiry, C., Carnazzi, E., Bergé, G., Gagne, D., Galleyrand, J.C., Martinez, J. J. Biol. Chem. (2005) [Pubmed]
  40. Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt. Liu, S., Premont, R.T., Kontos, C.D., Huang, J., Rockey, D.C. J. Biol. Chem. (2003) [Pubmed]
  41. Localization of functional endothelin receptor signaling complexes in cardiac transverse tubules. Robu, V.G., Pfeiffer, E.S., Robia, S.L., Balijepalli, R.C., Pi, Y., Kamp, T.J., Walker, J.W. J. Biol. Chem. (2003) [Pubmed]
  42. Gastrin stimulates tyrosine phosphorylation of insulin receptor substrate 1 and its association with Grb2 and the phosphatidylinositol 3-kinase. Kowalski-Chauvel, A., Pradayrol, L., Vaysse, N., Seva, C. J. Biol. Chem. (1996) [Pubmed]
  43. Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. Shen, Y., Monsma, F.J., Metcalf, M.A., Jose, P.A., Hamblin, M.W., Sibley, D.R. J. Biol. Chem. (1993) [Pubmed]
  44. Use of a sandwich enzyme-linked immunosorbent assay strategy to study mechanisms of G protein-coupled receptor assembly. Jakubik, J., Wess, J. J. Biol. Chem. (1999) [Pubmed]
  45. Adjuvant arthritis induces down-regulation of G protein-coupled receptor kinases in the immune system. Lombardi, M.S., Kavelaars, A., Cobelens, P.M., Schmidt, R.E., Schedlowski, M., Heijnen, C.J. J. Immunol. (2001) [Pubmed]
  46. Molecular cloning, tissue-specific expression, and chromosomal localization of a novel nerve growth factor-regulated G-protein- coupled receptor, nrg-1. Glickman, M., Malek, R.L., Kwitek-Black, A.E., Jacob, H.J., Lee, N.H. Mol. Cell. Neurosci. (1999) [Pubmed]
  47. Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family. Lachowicz, J.E., Shen, Y., Monsma, F.J., Sibley, D.R. J. Neurochem. (1995) [Pubmed]
WikiGenes - Universities