Animal models of multiple system atrophy.
Multiple system atrophy (MSA) is a fatal neurodegenerative disorder presenting with autonomic failure and motor impairment, primarily comprising L-dopa-resistant parkinsonism but occasionally involving cerebellar ataxia. These features result from progressive multisystem neuronal loss that is associated with oligodendroglial alpha-synuclein inclusions. The growing number of animal models for MSA reflects the search for a preclinical test-bed for elucidating MSA pathogenesis and for developing novel therapeutic interventions. Here, the currently available MSA animal models will be reviewed and leads for future research will be identified.[1]References
- Animal models of multiple system atrophy. Stefanova, N., Tison, F., Reindl, M., Poewe, W., Wenning, G.K. Trends Neurosci. (2005) [Pubmed]
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