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MeSH Review

Multiple System Atrophy

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Disease relevance of Multiple System Atrophy


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Chemical compound and disease context of Multiple System Atrophy


Biological context of Multiple System Atrophy


Anatomical context of Multiple System Atrophy


Gene context of Multiple System Atrophy


Analytical, diagnostic and therapeutic context of Multiple System Atrophy


  1. Failure of the clonidine growth hormone stimulation test to differentiate multiple system atrophy from early or advanced idiopathic Parkinson's disease. Clarke, C.E., Ray, P.S., Speller, J.M. Lancet (1999) [Pubmed]
  2. Differing patterns of striatal 18F-dopa uptake in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. Brooks, D.J., Ibanez, V., Sawle, G.V., Quinn, N., Lees, A.J., Mathias, C.J., Bannister, R., Marsden, C.D., Frackowiak, R.S. Ann. Neurol. (1990) [Pubmed]
  3. Spinocerebellar ataxia type 1 with multiple system degeneration and glial cytoplasmic inclusions. Gilman, S., Sima, A.A., Junck, L., Kluin, K.J., Koeppe, R.A., Lohman, M.E., Little, R. Ann. Neurol. (1996) [Pubmed]
  4. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein. Tu, P.H., Galvin, J.E., Baba, M., Giasson, B., Tomita, T., Leight, S., Nakajo, S., Iwatsubo, T., Trojanowski, J.Q., Lee, V.M. Ann. Neurol. (1998) [Pubmed]
  5. Chronic stimulation of D1 dopamine receptors in human SK-N-MC neuroblastoma cells induces nitric-oxide synthase activation and cytotoxicity. Chen, J., Wersinger, C., Sidhu, A. J. Biol. Chem. (2003) [Pubmed]
  6. Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative diseases affecting the basal ganglia. The Royal Kings and Queens Parkinson's Disease Research Group. Dexter, D.T., Jenner, P., Schapira, A.H., Marsden, C.D. Ann. Neurol. (1992) [Pubmed]
  7. Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis. Hishikawa, N., Niwa, J., Doyu, M., Ito, T., Ishigaki, S., Hashizume, Y., Sobue, G. Am. J. Pathol. (2003) [Pubmed]
  8. Synucleins in synaptic plasticity and neurodegenerative disorders. Clayton, D.F., George, J.M. J. Neurosci. Res. (1999) [Pubmed]
  9. Treatment of erectile dysfunction with sildenafil citrate (Viagra) in parkinsonism due to Parkinson's disease or multiple system atrophy with observations on orthostatic hypotension. Hussain, I.F., Brady, C.M., Swinn, M.J., Mathias, C.J., Fowler, C.J. J. Neurol. Neurosurg. Psychiatr. (2001) [Pubmed]
  10. Overexpression of the alpha1B-adrenergic receptor causes apoptotic neurodegeneration: multiple system atrophy. Zuscik, M.J., Sands, S., Ross, S.A., Waugh, D.J., Gaivin, R.J., Morilak, D., Perez, D.M. Nat. Med. (2000) [Pubmed]
  11. Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration. Yazawa, I., Giasson, B.I., Sasaki, R., Zhang, B., Joyce, S., Uryu, K., Trojanowski, J.Q., Lee, V.M. Neuron (2005) [Pubmed]
  12. Increased numbers of alpha receptors in sympathetic denervation supersensitivity in man. Davies, B., Sudera, D., Sagnella, G., Marchesi-Saviotti, E., Mathias, C., Bannister, R., Sever, P. J. Clin. Invest. (1982) [Pubmed]
  13. False-positive SCA8 gene test in a patient with pathologically proven multiple system atrophy. Factor, S.A., Qian, J., Lava, N.S., Hubbard, J.D., Payami, H. Ann. Neurol. (2005) [Pubmed]
  14. Accumulation of 14-3-3 proteins in glial cytoplasmic inclusions in multiple system atrophy. Kawamoto, Y., Akiguchi, I., Nakamura, S., Budka, H. Ann. Neurol. (2002) [Pubmed]
  15. Dopa resistance in multiple-system atrophy: loss of postsynaptic D2 receptors. Churchyard, A., Donnan, G.A., Hughes, A., Howells, D.W., Woodhouse, D., Wong, J.Y., Kalnins, R.M., Mendelsohn, F.A., Paxinos, G. Ann. Neurol. (1993) [Pubmed]
  16. Blood pressure and vasopressin in progressive autonomic failure. Response to postural stimulation, L-dopa and naloxone. Puritz, R., Lightman, S.L., Wilcox, C.S., Forsling, M., Bannister, R. Brain (1983) [Pubmed]
  17. Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene. Shashidharan, P., Michaelidis, T.M., Robakis, N.K., Kresovali, A., Papamatheakis, J., Plaitakis, A. J. Biol. Chem. (1994) [Pubmed]
  18. Valproic acid toxicity mimicking multiple system atrophy. Manto, M.U., Moore, J. Neurology (2001) [Pubmed]
  19. Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy. Stefanova, N., Reindl, M., Neumann, M., Haass, C., Poewe, W., Kahle, P.J., Wenning, G.K. Am. J. Pathol. (2005) [Pubmed]
  20. Effect of the somatostatin analogue SMS-201-995 on the adrenergic response to glucose ingestion in patients with postprandial hypotension. Hoeldtke, R.D., Dworkin, G.E., Gaspar, S.R., Israel, B.C., Boden, G. Am. J. Med. (1989) [Pubmed]
  21. Not paralysis, but dystonia causes stridor in multiple system atrophy. Merlo, I.M., Occhini, A., Pacchetti, C., Alfonsi, E. Neurology (2002) [Pubmed]
  22. Multiple system atrophy/progressive supranuclear palsy: alpha-Synuclein, synphilin, tau, and APOE. Morris, H.R., Vaughan, J.R., Datta, S.R., Bandopadhyay, R., Rohan De Silva, H.A., Schrag, A., Cairns, N.J., Burn, D., Nath, U., Lantos, P.L., Daniel, S., Lees, A.J., Quinn, N.P., Wood, N.W. Neurology (2000) [Pubmed]
  23. Cloning and mapping of ZNF231, a novel brain-specific gene encoding neuronal double zinc finger protein whose expression is enhanced in a neurodegenerative disorder, multiple system atrophy (MSA). Hashida, H., Goto, J., Zhao, N., Takahashi, N., Hirai, M., Kanazawa, I., Sakaki, Y. Genomics (1998) [Pubmed]
  24. Benzodiazepine receptor binding in cerebellar degenerations studied with positron emission tomography. Gilman, S., Koeppe, R.A., Junck, L., Kluin, K.J., Lohman, M., St Laurent, R.T. Ann. Neurol. (1995) [Pubmed]
  25. Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. Souza, J.M., Giasson, B.I., Chen, Q., Lee, V.M., Ischiropoulos, H. J. Biol. Chem. (2000) [Pubmed]
  26. Hypotension-induced vasopressin release distinguishes between pure autonomic failure and multiple system atrophy with autonomic failure. Kaufmann, H., Oribe, E., Miller, M., Knott, P., Wiltshire-Clement, M., Yahr, M.D. Neurology (1992) [Pubmed]
  27. Marked depletion of dorsal spinal cord substance P and calcitonin gene-related peptide with intact skin flare responses in multiple system atrophy. Anand, P., Bannister, R., McGregor, G.P., Ghatei, M.A., Mulderry, P.K., Bloom, S.R. J. Neurol. Neurosurg. Psychiatr. (1988) [Pubmed]
  28. Characterization of glutamate dehydrogenase isoproteins purified from the cerebellum of normal subjects and patients with degenerative neurological disorders, and from human neoplastic cell lines. Hussain, M.M., Zannis, V.I., Plaitakis, A. J. Biol. Chem. (1989) [Pubmed]
  29. alpha-Synuclein forms a complex with transcription factor Elk-1. Iwata, A., Miura, S., Kanazawa, I., Sawada, M., Nukina, N. J. Neurochem. (2001) [Pubmed]
  30. Spinocerebellar ataxia type 14 caused by a mutation in protein kinase C gamma. Yabe, I., Sasaki, H., Chen, D.H., Raskind, W.H., Bird, T.D., Yamashita, I., Tsuji, S., Kikuchi, S., Tashiro, K. Arch. Neurol. (2003) [Pubmed]
  31. Glial cell line-derived neurotrophic factor-like immunoreactivity in the cerebella of normal subjects and patients with multiple system atrophy. Kawamoto, Y., Nakamura, S., Matsuo, A., Akiguchi, I. Acta Neuropathol. (2000) [Pubmed]
  32. Fragile X gene premutation in multiple system atrophy. Garland, E.M., Vnencak-Jones, C.L., Biaggioni, I., Davis, T.L., Montine, T.J., Robertson, D. J. Neurol. Sci. (2004) [Pubmed]
  33. Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies. Sampathu, D.M., Giasson, B.I., Pawlyk, A.C., Trojanowski, J.Q., Lee, V.M. Am. J. Pathol. (2003) [Pubmed]
  34. Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies. Kovács, G.G., László, L., Kovács, J., Jensen, P.H., Lindersson, E., Botond, G., Molnár, T., Perczel, A., Hudecz, F., Mezo, G., Erdei, A., Tirián, L., Lehotzky, A., Gelpi, E., Budka, H., Ovádi, J. Neurobiol. Dis. (2004) [Pubmed]
  35. [(123)I]beta-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's disease and multiple system atrophy. Varrone, A., Marek, K.L., Jennings, D., Innis, R.B., Seibyl, J.P. Mov. Disord. (2001) [Pubmed]
  36. Haemodynamic responses during head-up tilt and tilt reversal in two groups with chronic autonomic failure: pure autonomic failure and multiple system atrophy. Chandler, M.P., Mathias, C.J. J. Neurol. (2002) [Pubmed]
  37. Tc-99m ethylene cysteinate dimer SPECT in the differential diagnosis of parkinsonism. Feigin, A., Antonini, A., Fukuda, M., De Notaris, R., Benti, R., Pezzoli, G., Mentis, M.J., Moeller, J.R., Eidelberg, D. Mov. Disord. (2002) [Pubmed]
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