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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity.

A set of quinolizidinyl and quinolizidinylalkyl derivatives of 4-amino-7-chloroquinoline and of 9-amino-6-chloro-2-methoxyacridine were prepared and tested in vitro against CQ-sensitive (D-10) and CQ-resistant (W-2) strains of Plasmodium falciparum. All compounds but one exerted significant antimalarial activity. Some of the quinolizidine derivatives were from 5 to 10 times more active than chloroquine on the CQ-resistant strain. No toxicity against mammalian cells was observed.[1]

References

  1. 4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity. Sparatore, A., Basilico, N., Parapini, S., Romeo, S., Novelli, F., Sparatore, F., Taramelli, D. Bioorg. Med. Chem. (2005) [Pubmed]
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