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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Maturation of Borna disease virus glycoprotein.

The maturation of Borna disease virus (BDV) glycoprotein GP was studied in regard to intracellular compartmentalization, compartmentalization signal-domains, proteolytic processing, and packaging into virus particles. Our data show that BDV-GP is (i) predominantly located in the endoplasmic reticulum (ER), (ii) partially exists in the ER already as cleaved subunits GP-N and GP-C, (iii) is directed to the ER/cis-Golgi region by its transmembrane and/or cytoplasmic domains in CD8-BDV-GP hybrid constructs and (iv) is incorporated in the virus particles as authentic BDV glycoprotein exclusively in the cleaved form decorated with N-glycans of the complex type. Downregulation of BDV-glycoproteins on the cell surface, their limited proteolytic processing, and protection of antigenic epitopes on the viral glycoproteins by host-identical N-glycans are different strategies for persistent virus infections.[1]


  1. Maturation of Borna disease virus glycoprotein. Eickmann, M., Kiermayer, S., Kraus, I., Gössl, M., Richt, J.A., Garten, W. FEBS Lett. (2005) [Pubmed]
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