- Transthyretin-related proteins function to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction. Lee, Y., Lee, d.o. .H., Kho, C.W., Lee, A.Y., Jang, M., Cho, S., Lee, C.H., Lee, J.S., Myung, P.K., Park, B.C., Park, S.G. FEBS Lett. (2005)