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Chemical Compound Review

SureCN997117     5-hydroxy-3,7-dihydropurine- 2,6,8-trione

Synonyms: AG-K-66973, CHEBI:18072, NSC-69826, SureCN11959537, AC1L5HKI, ...
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Disease relevance of C11821


High impact information on C11821

  • We report the identification and purification of a novel enzyme from soybean root nodules that catalyzes the hydrolysis of 5-hydroxyisourate, which is the true product of the urate oxidase reaction [3].
  • The purified enzyme obeyed normal Michaelis-Menten kinetics, and the K(m) for 5-hydroxyisourate was determined to be 15 microM [3].
  • However, a homologous family of transthyretin-like proteins (TLPs) present in bacteria as well as eukaryotes do not bind thyroid hormones, instead they are postulated to perform a role in the purine degradation pathway and function as 5-hydroxyisourate hydrolases [2].
  • The product of the reaction, 5-hydroxyisourate, is fluorescent, and its release from the active site occurred with a rate constant of 31 s-1 [4].
  • Transthyretin-related proteins function to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction [5].

Associations of C11821 with other chemical compounds


Gene context of C11821


  1. Structural and functional analysis of PucM, a hydrolase in the ureide pathway and a member of the transthyretin-related protein family. Jung, D.K., Lee, Y., Park, S.G., Park, B.C., Kim, G.H., Rhee, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. The crystal structure of the transthyretin-like protein from Salmonella dublin, a prokaryote 5-hydroxyisourate hydrolase. Hennebry, S.C., Law, R.H., Richardson, S.J., Buckle, A.M., Whisstock, J.C. J. Mol. Biol. (2006) [Pubmed]
  3. Identification and purification of hydroxyisourate hydrolase, a novel ureide-metabolizing enzyme. Sarma, A.D., Serfozo, P., Kahn, K., Tipton, P.A. J. Biol. Chem. (1999) [Pubmed]
  4. Spectroscopic characterization of intermediates in the urate oxidase reaction. Kahn, K., Tipton, P.A. Biochemistry (1998) [Pubmed]
  5. Transthyretin-related proteins function to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction. Lee, Y., Lee, d.o. .H., Kho, C.W., Lee, A.Y., Jang, M., Cho, S., Lee, C.H., Lee, J.S., Myung, P.K., Park, B.C., Park, S.G. FEBS Lett. (2005) [Pubmed]
  6. Recapture of [S]-allantoin, the product of the two-step degradation of uric acid, by urate oxidase. Gabison, L., Chiadmi, M., Colloc'h, N., Castro, B., El Hajji, M., Prangé, T. FEBS Lett. (2006) [Pubmed]
  7. Mouse Transthyretin-related Protein Is a Hydrolase which Degrades 5-Hydroxyisourate, the End Product of the Uricase Reaction. Lee, Y., Park, B.C., Lee, d.o. .H., Bae, K.H., Cho, S., Lee, C.H., Lee, J.S., Myung, P.K., Park, S.G. Mol. Cells (2006) [Pubmed]
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