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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Leukocytoclastic vasculitis: a rare manifestation of propylthiouracil hypersensitivity.

OBJECTIVE: We report a case of leukocytoclastic vasculitis as a manifestation of propylthiouracil hypersensitivity. CLINICAL PRESENTATION AND INTERVENTION: A 66-year-old woman with a history of a toxic adenoma was referred for evaluation of a purpuric rash on the legs and buttocks bilaterally. She was biochemically hyperthyroid. Biopsy of the skin lesions revealed leukocytoclastic vasculitis. Propylthiouracil therapy was discontinued, and methimazole started. The purpuric rash resolved and surgical treatment for toxic adenoma resulted in euthyroid state. CONCLUSION: This report indicated that leukocytoclastic vasculitis should be considered in the differential diagnosis of patients with a vasculitic rash. The discontinuation of the propylthiouracil was associated with disappearance of the lesions.[1]


  1. Leukocytoclastic vasculitis: a rare manifestation of propylthiouracil hypersensitivity. Erem, C., Yucel, Y., Ya, Z., Reis, A., Kocak, M., Hacihasanoglu, A. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. (2005) [Pubmed]
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