Disease relevance of Vasculitis, Hypersensitivity

• An IgG3 monoclonal antibody, 6-19, derived from unmanipulated MRL/MpJ-lpr/lpr mice, exhibiting cryoglobulin and anti-IgG2a rheumatoid factor activities, induces skin leukocytoclastic vasculitis and glomerulonephritis when injected into normal mice [1].
• Behçet's syndrome complicated by cutaneous leukocytoclastic vasculitis. Response to prednisone and chlorambucil [2].
• The key histological features were within the adventitia: leukocytoclastic vasculitis of the vasa vasora and periadventitial vessels, proliferation of slit-like vascular channels, chronic inflammation, and fibrosis [3].
• A patient with leukocytoclastic vasculitis (LCV) with secondary mixed cryoglobulinemia was treated by cryofiltration in an effort to stop the progression of the disease despite the use of high dose prednisone [4].
• Hepatitis C virus (HCV) in cryoglobulinaemic leukocytoclastic vasculitis (LCV): could the presence of HCV in skin lesions be related to T CD8+ lymphocytes, HLA-DR and ICAM-1 expression [5]?

High impact information on Vasculitis, Hypersensitivity

• Leukocytoclastic vasculitis after high-dose methotrexate [6].
• We therefore hypothesized that PTX3 accumulates at sites of leukocytoclastic vasculitis and, as such, is a key factor for the induction of leukocytoclasis [7].
• Mice implanted with hybridoma secreting 6-19 IgG3 anti-IgG2a rheumatoid factor (RF) with cryoglobulin activity develop acute glomerulonephritis and cutaneous leukocytoclastic vasculitis [8].
• Orlistat-induced cutaneous leukocytoclastic vasculitis [9].
• These results indicate that Fc gamma RIII plays a major role in the pathogenesis of leukocytoclastic vasculitis [10].

Chemical compound and disease context of Vasculitis, Hypersensitivity

• Histologic examination revealed leukocytoclastic vasculitis with deposition of C3, IgA, and/or IgM in the small dermal vessels [11].
• Zidovudine-induced leukocytoclastic vasculitis [12].
• Efavirenz-induced leukocytoclastic vasculitis [13].
• Leukocytoclastic vasculitis associated with nizatidine therapy [14].
• Leukotriene B4 and 12-HETE led to massive histologic changes characteristic of leukocytoclastic vasculitis [15].

Biological context of Vasculitis, Hypersensitivity

• RESULTS: Biopsy specimens from patients with leukocytoclastic vasculitis revealed an abundant up-regulation of PTX3 at sites of leukocytoclastic infiltrates [7].
• Although immunoglobulin G2 is the predominant subtype precipitated at endothelial surfaces, it is not required for fixing circulating immune complexes to endothelium, because patients homozygote for Fc gamma receptor IIa-arginine 131 equally develop leukocytoclastic vasculitis as those bearing the Fc gamma receptor IIa-histidine 131 allele [16].

Anatomical context of Vasculitis, Hypersensitivity

• The effect of sera from patients with untreated leukocytoclastic vasculitis was investigated on the generation of oxygen intermediates by normal polymorphonuclear leukocytes [17].

Gene context of Vasculitis, Hypersensitivity

• Proliferative lupus nephritis and leukocytoclastic vasculitis during treatment with etanercept [18].
• We describe the first case of leukocytoclastic vasculitis associated with the use of etanercept in a patient with severe, deforming RA previously unresponsive to multiple therapies [19].
• OBJECTIVE: To describe the clinical features of leukocytoclastic vasculitis (LCV) associated with the use of tumor necrosis factor-alpha (TNF-alpha) blockers [20].
• ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leukocytoclastic vasculitis in NZBxNZWF1 mice [21].
• Keywords: CD32/immunoglobulin G subtypes/leukocytoclastic vasculitis/microvessels [16].

Analytical, diagnostic and therapeutic context of Vasculitis, Hypersensitivity

• Necrotizing leukocytoclastic vasculitis with positive immunofluorescence studies was found only in 2 biopsies from 1 patient who was genetically deficient in C4 [22].

References