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MeSH Review

Vasculitis, Hypersensitivity

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Disease relevance of Vasculitis, Hypersensitivity


High impact information on Vasculitis, Hypersensitivity


Chemical compound and disease context of Vasculitis, Hypersensitivity


Biological context of Vasculitis, Hypersensitivity

  • RESULTS: Biopsy specimens from patients with leukocytoclastic vasculitis revealed an abundant up-regulation of PTX3 at sites of leukocytoclastic infiltrates [7].
  • Although immunoglobulin G2 is the predominant subtype precipitated at endothelial surfaces, it is not required for fixing circulating immune complexes to endothelium, because patients homozygote for Fc gamma receptor IIa-arginine 131 equally develop leukocytoclastic vasculitis as those bearing the Fc gamma receptor IIa-histidine 131 allele [16].

Anatomical context of Vasculitis, Hypersensitivity


Gene context of Vasculitis, Hypersensitivity


Analytical, diagnostic and therapeutic context of Vasculitis, Hypersensitivity


  1. Immunoglobulin heavy chain constant region determines the pathogenicity and the antigen-binding activity of rheumatoid factor. Fulpius, T., Spertini, F., Reininger, L., Izui, S. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Behçet's syndrome complicated by cutaneous leukocytoclastic vasculitis. Response to prednisone and chlorambucil. Plotkin, G.R., Patel, B.R., Shah, V.N. Arch. Intern. Med. (1985) [Pubmed]
  3. Large artery vasculopathy in HIV-positive patients: another vasculitic enigma. Chetty, R., Batitang, S., Nair, R. Hum. Pathol. (2000) [Pubmed]
  4. Rapid improvement in a patient with leukocytoclastic vasculitis with secondary mixed cryoglobulinemia treated with cryofiltration. Sawada, K., Segal, A.M., Malchesky, P.S., Koo, A.P., Naganuma, S., Nosé, Y. J. Rheumatol. (1991) [Pubmed]
  5. Hepatitis C virus (HCV) in cryoglobulinaemic leukocytoclastic vasculitis (LCV): could the presence of HCV in skin lesions be related to T CD8+ lymphocytes, HLA-DR and ICAM-1 expression? Bernacchi, E., Civita, L.L., Caproni, M., Zignego, A.L., Bianchi, B., Monti, M., Fabbri, P., Pasero, G., Ferri, C. Exp. Dermatol. (1999) [Pubmed]
  6. Leukocytoclastic vasculitis after high-dose methotrexate. Navarro, M., Pedragosa, R., Lafuerza, A., Rubio, D., Huguet, P. Ann. Intern. Med. (1986) [Pubmed]
  7. Abundance of the long pentraxin PTX3 at sites of leukocytoclastic lesions in patients with small-vessel vasculitis. van Rossum, A.P., Pas, H.H., Fazzini, F., Huitema, M.G., Limburg, P.C., Jonkman, M.F., Kallenberg, C.G. Arthritis Rheum. (2006) [Pubmed]
  8. A transgenic mouse model of autoimmune glomerulonephritis and necrotizing arteritis associated with cryoglobulinemia. Kikuchi, S., Pastore, Y., Fossati-Jimack, L., Kuroki, A., Yoshida, H., Fulpius, T., Araki, K., Takahashi, S., Lemoine, R., Reininger, L., Izui, S. J. Immunol. (2002) [Pubmed]
  9. Orlistat-induced cutaneous leukocytoclastic vasculitis. Gonzalez-Gay, M.A., Garcia-Porrua, C., Lueiro, M., Fernandez, M.L. Arthritis Rheum. (2002) [Pubmed]
  10. Fc gamma receptor activation of neutrophils in cryoglobulin-induced leukocytoclastic vasculitis. Hundt, M., Zielinska-Skowronek, M., Schmidt, R.E. Arthritis Rheum. (1993) [Pubmed]
  11. Quinidine-induced vasculitis. Shalit, M., Flugelman, M.Y., Harats, N., Galun, E., Ackerman, Z., Kopolovic, J., Eliakim, M. Arch. Intern. Med. (1985) [Pubmed]
  12. Zidovudine-induced leukocytoclastic vasculitis. Torres, R.A., Lin, R.Y., Lee, M., Barr, M.R. Arch. Intern. Med. (1992) [Pubmed]
  13. Efavirenz-induced leukocytoclastic vasculitis. Domingo, P., Barceló, M. Arch. Intern. Med. (2002) [Pubmed]
  14. Leukocytoclastic vasculitis associated with nizatidine therapy. Suh, J.G., Oleksowicz, L., Dutcher, J.P. Am. J. Med. (1997) [Pubmed]
  15. Effects of chronic intracutaneous administration of arachidonic acid and its metabolites. Induction of leukocytoclastic vasculitis by leukotriene B4 and 12-hydroxyeicosatetraenoic acid and its prevention by prostaglandin E2. Ruzicka, T., Burg, G. J. Invest. Dermatol. (1987) [Pubmed]
  16. Immune complexes from vasculitis patients bind to endothelial Fc receptors independent of the allelic polymorphism of FcgammaRIIa. Gröger, M., Fischer, G.F., Wolff, K., Petzelbauer, P. J. Invest. Dermatol. (1999) [Pubmed]
  17. Increased hydroxyl radical generation by normal polymorphonuclear leukocytes incubated in sera from patients with leukocytoclastic vasculitis. Miyachi, Y., Yanase, K., Imamura, S., Niwa, Y. Arch. Dermatol. Res. (1982) [Pubmed]
  18. Proliferative lupus nephritis and leukocytoclastic vasculitis during treatment with etanercept. Mor, A., Bingham, C., Barisoni, L., Lydon, E., Belmont, H.M. J. Rheumatol. (2005) [Pubmed]
  19. Leukocytoclastic vasculitis due to etanercept. Galaria, N.A., Werth, V.P., Schumacher, H.R. J. Rheumatol. (2000) [Pubmed]
  20. Leukocytoclastic vasculitis associated with tumor necrosis factor-alpha blocking agents. Mohan, N., Edwards, E.T., Cupps, T.R., Slifman, N., Lee, J.H., Siegel, J.N., Braun, M.M. J. Rheumatol. (2004) [Pubmed]
  21. ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leukocytoclastic vasculitis in NZBxNZWF1 mice. Hayashi, T., Hasegawa, K., Ichinohe, N. Histol. Histopathol. (2005) [Pubmed]
  22. Urticarial pathology in Schnitzler's (hyper-IgM) syndrome. de Castro, F.R., Masouyé, I., Winkelmann, R.K., Saurat, J.H. Dermatology (Basel) (1996) [Pubmed]
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