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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

TLR ignores methylated RNA?

CpG methylation of DNA silences TLR9-mediated innate immune recognition. In this issue of Immunity, Kariko et al (2005) suggest that the innate immune recognition of RNA by TLR3, TLR7, or TLR8 is in fact controlled by modification of nucleotides, including methylation.[1]


  1. TLR ignores methylated RNA? Ishii, K.J., Akira, S. Immunity (2005) [Pubmed]
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