Gene Review:
TLR8 - toll-like receptor 8
Homo sapiens
Synonyms:
CD288, Toll-like receptor 8, UNQ249/PRO286
Kabelitz,
Schön,
Schön,
Klotz,
Jurk,
Kritzler,
Schulte,
Tluk,
Schetter,
Krieg,
Vollmer,
Levy,
Suter,
Miller,
Wessels,
Karikó,
Buckstein,
Ni,
Weissman,
Sioud,
Fl??isand,
Forfang,
Lund-Johansen,
Triantafilou,
Vakakis,
Orthopoulos,
Ahmed,
Schumann,
Lepper,
Triantafilou,
Nagase,
Okugawa,
Ota,
Yamaguchi,
Tomizawa,
Matsushima,
Ohta,
Yamamoto,
Hirai,
- Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats. Hammerbeck, D.M., Burleson, G.R., Schuller, C.J., Vasilakos, J.P., Tomai, M., Egging, E., Cochran, F.R., Woulfe, S., Miller, R.L. Antiviral Res. (2007)
- TLR8 and TLR7 are involved in the host's immune response to human parechovirus 1. Triantafilou, K., Vakakis, E., Orthopoulos, G., Ahmed, M.A., Schumann, C., Lepper, P.M., Triantafilou, M. Eur. J. Immunol. (2005)
- Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Karikó, K., Buckstein, M., Ni, H., Weissman, D. Immunity (2005)
- A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. Gautier, G., Humbert, M., Deauvieau, F., Scuiller, M., Hiscott, J., Bates, E.E., Trinchieri, G., Caux, C., Garrone, P. J. Exp. Med. (2005)
- Expression and function of Toll-like receptors in T lymphocytes. Kabelitz, D. Curr. Opin. Immunol. (2007)
- Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. Ma, Y., Li, J., Chiu, I., Wang, Y., Sloane, J.A., L??, J., Kosaras, B., Sidman, R.L., Volpe, J.J., Vartanian, T. J. Cell Biol. (2006)
- Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells. Levy, O., Suter, E.E., Miller, R.L., Wessels, M.R. Blood (2006)
- Conserved Features in the Extracellular Domain of Human Toll-like Receptor 8 Are Essential for pH-dependent Signaling. Gibbard, R.J., Morley, P.J., Gay, N.J. J. Biol. Chem. (2006)
- Signaling through Toll-like Receptor 7/8 Induces the Differentiation of Human Bone Marrow CD34+ Progenitor Cells along the Myeloid Lineage. Sioud, M., Fl??isand, Y., Forfang, L., Lund-Johansen, F. J. Mol. Biol. (2006)
- Three novel mammalian toll-like receptors: gene structure, expression, and evolution. Du, X., Poltorak, A., Wei, Y., Beutler, B. Eur. Cytokine Netw. (2000)
- Expression and function of Toll-like receptors in eosinophils: activation by Toll-like receptor 7 ligand. Nagase, H., Okugawa, S., Ota, Y., Yamaguchi, M., Tomizawa, H., Matsushima, K., Ohta, K., Yamamoto, K., Hirai, K. J. Immunol. (2003)
- The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Heil, F., Ahmad-Nejad, P., Hemmi, H., Hochrein, H., Ampenberger, F., Gellert, T., Dietrich, H., Lipford, G., Takeda, K., Akira, S., Wagner, H., Bauer, S. Eur. J. Immunol. (2003)
- Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Peng, G., Guo, Z., Kiniwa, Y., Voo, K.S., Peng, W., Fu, T., Wang, D.Y., Li, Y., Wang, H.Y., Wang, R.F. Science (2005)
- Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Lee, J., Chuang, T.H., Redecke, V., She, L., Pitha, P.M., Carson, D.A., Raz, E., Cottam, H.B. Proc. Natl. Acad. Sci. U.S.A. (2003)
- The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion. Schön, M.P., Schön, M., Klotz, K.N. J. Invest. Dermatol. (2006)
- Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides. Jurk, M., Kritzler, A., Schulte, B., Tluk, S., Schetter, C., Krieg, A.M., Vollmer, J. Eur. J. Immunol. (2006)
- The Functional Effects of Physical Interactions among Toll-like Receptors 7, 8, and 9. Wang, J., Shao, Y., Bennett, T.A., Shankar, R.A., Wightman, P.D., Reddy, L.G. J. Biol. Chem. (2006)
- Expression of Toll-like receptors and their association with cytokine responses in peripheral blood mononuclear cells of children with acute rotavirus diarrhoea. Xu, J., Yang, Y., Sun, J., Ding, Y., Su, L., Shao, C., Jiang, B. Clin. Exp. Immunol. (2006)
- Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4. Jefferies, C.A., Doyle, S., Brunner, C., Dunne, A., Brint, E., Wietek, C., Walch, E., Wirth, T., O'Neill, L.A. J. Biol. Chem. (2003)
- Oligodeoxynucleotides Differentially Modulate Activation of TLR7 and TLR8 by Imidazoquinolines. Gorden, K.K., Qiu, X., Battiste, J.J., Wightman, P.P., Vasilakos, J.P., Alkan, S.S. J. Immunol. (2006)
- Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. Chuang, T.H., Ulevitch, R.J. Eur. Cytokine Netw. (2000)