Gene Review:
TLR9 - toll-like receptor 9
Homo sapiens
Synonyms:
CD289, Toll-like receptor 9, UNQ5798/PRO19605
Smedsrød,
Jego,
Simon-Santamaria,
Matthiessen,
Schito,
Banas,
Vodovotz,
Green,
van Heel,
Pettersen,
Nakashima,
Gong,
Forbes,
Matsukawa,
Sher,
Bauer,
Chorny,
Liu,
Moens,
Gallo,
Pellat-Deceunynck,
Williams,
Kirschning,
Andresen,
Anders,
Arditi,
Geffroy-Luseau,
Montreekachon,
Rask-Madsen,
Madak,
Vermeulen,
Playford,
Salamone,
Gambotto,
Wong,
Pedersen,
Hunt,
Ghosh,
Equils,
Brynskov,
Hughes,
Gantner,
Martin-Armas,
Schettini,
Bataille,
Yarali,
Fukuda,
Descamps,
Humphris,
Liu,
Page,
Gamberale,
Sa-Ard-Iam,
Pichyangkul,
Hermann,
Billiar,
Bacon,
Trevani,
Geffner,
Jewell,
Sveinbjørnsson,
Hermann Wagner,
Karahashi,
Raiden,
Sakai,
Schlöndorff,
Michelsen,
Mathew,
Lierl,
Yongvanichit,
Mahanonda,
Pimkhaokham,
Shapiro,
Parilla,
- Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. Lund, J., Sato, A., Akira, S., Medzhitov, R., Iwasaki, A. J. Exp. Med. (2003)
- HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates. Wille-Reece, U., Flynn, B.J., Loré, K., Koup, R.A., Kedl, R.M., Mattapallil, J.J., Weiss, W.R., Roederer, M., Seder, R.A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells. Bourke, E., Bosisio, D., Golay, J., Polentarutti, N., Mantovani, A. Blood (2003)
- Signaling danger: toll-like receptors and their potential roles in kidney disease. Anders, H.J., Banas, B., Schlöndorff, D. J. Am. Soc. Nephrol. (2004)
- Toll-like receptor 9 (TLR9) is present in murine liver sinusoidal endothelial cells (LSECs) and mediates the effect of CpG-oligonucleotides. Martin-Armas, M., Simon-Santamaria, J., Pettersen, I., Moens, U., Smedsrød, B., Sveinbjørnsson, B. J. Hepatol. (2006)
- IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Liu, Y.J. Annu. Rev. Immunol. (2005)
- Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Hornung, V., Guenthner-Biller, M., Bourquin, C., Ablasser, A., Schlee, M., Uematsu, S., Noronha, A., Manoharan, M., Akira, S., de Fougerolles, A., Endres, S., Hartmann, G. Nat. Med. (2005)
- A Toll-like receptor recognizes bacterial DNA. Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., Akira, S. Nature (2000)
- Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus. Christensen, S.R., Shupe, J., Nickerson, K., Kashgarian, M., Flavell, R.A., Shlomchik, M.J. Immunity (2006)
- Novel toll-like receptor 9 agonist induces epidermal growth factor receptor (EGFR) inhibition and synergistic antitumor activity with EGFR inhibitors. Damiano, V., Caputo, R., Bianco, R., D'Armiento, F.P., Leonardi, A., De Placido, S., Bianco, A.R., Agrawal, S., Ciardiello, F., Tortora, G. Clin. Cancer Res. (2006)
- Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. Rutz, M., Metzger, J., Gellert, T., Luppa, P., Lipford, G.B., Wagner, H., Bauer, S. Eur. J. Immunol. (2004)
- Critical role of Toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury. Velayudham, A., Hritz, I., Dolganiuc, A., Mandrekar, P., Kurt-Jones, E., Szabo, G. J. Hepatol. (2006)
- Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Ahmad-Nejad, P., Häcker, H., Rutz, M., Bauer, S., Vabulas, R.M., Wagner, H. Eur. J. Immunol. (2002)
- TLR9-based immunotherapy for allergic disease. Hayashi, T., Raz, E. Am. J. Med. (2006)
- Collaborative Action of NF-{kappa}B and p38 MAPK Is Involved in CpG DNA-Induced IFN-{alpha} and Chemokine Production in Human Plasmacytoid Dendritic Cells. Osawa, Y., Iho, S., Takauji, R., Takatsuka, H., Yamamoto, S., Takahashi, T., Horiguchi, S., Urasaki, Y., Matsuki, T., Fujieda, S. J. Immunol. (2006)
- Toll-like receptor 2 (TLR2) and TLR9 signaling results in HIV-long terminal repeat trans-activation and HIV replication in HIV-1 transgenic mouse spleen cells: implications of simultaneous activation of TLRs on HIV replication. Equils, O., Schito, M.L., Karahashi, H., Madak, Z., Yarali, A., Michelsen, K.S., Sher, A., Arditi, M. J. Immunol. (2003)
- Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors. Jego, G., Bataille, R., Geffroy-Luseau, A., Descamps, G., Pellat-Deceunynck, C. Leukemia (2006)
- Toll-like receptor 9 can be expressed at the cell surface of distinct populations of tonsils and human peripheral blood mononuclear cells. Eaton-Bassiri, A., Dillon, S.B., Cunningham, M., Rycyzyn, M.A., Mills, J., Sarisky, R.T., Mbow, M.L. Infect. Immun. (2004)
- Toll-like receptors induce a phagocytic gene program through p38. Doyle, S.E., O'Connell, R.M., Miranda, G.A., Vaidya, S.A., Chow, E.K., Liu, P.T., Suzuki, S., Suzuki, N., Modlin, R.L., Yeh, W.C., Lane, T.F., Cheng, G. J. Exp. Med. (2004)
- IFN-alpha regulates TLR-dependent gene expression of IFN-alpha, IFN-beta, IL-28, and IL-29. Sirén, J., Pirhonen, J., Julkunen, I., Matikainen, S. J. Immunol. (2005)
- Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. Hornung, V., Rothenfusser, S., Britsch, S., Krug, A., Jahrsdörfer, B., Giese, T., Endres, S., Hartmann, G. J. Immunol. (2002)
- Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease. van Heel, D.A., Ghosh, S., Hunt, K.A., Mathew, C.G., Forbes, A., Jewell, D.P., Playford, R.J. Gut (2005)
- Selective induction of tumor necrosis receptor factor 6/decoy receptor 3 release by bacterial antigens in human monocytes and myeloid dendritic cells. Kim, S., McAuliffe, W.J., Zaritskaya, L.S., Moore, P.A., Zhang, L., Nardelli, B. Infect. Immun. (2004)
- Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Lee, J., Chuang, T.H., Redecke, V., She, L., Pitha, P.M., Carson, D.A., Raz, E., Cottam, H.B. Proc. Natl. Acad. Sci. U.S.A. (2003)
- CpG DNA modulates interleukin 1beta-induced interleukin-8 expression in human bronchial epithelial (16HBE14o-) cells. Parilla, N.W., Hughes, V.S., Lierl, K.M., Wong, H.R., Page, K. Respir. Res. (2006)
- Expression of Toll-like receptor 9 and response to bacterial CpG oligodeoxynucleotides in human intestinal epithelium. Pedersen, G., Andresen, L., Matthiessen, M.W., Rask-Madsen, J., Brynskov, J. Clin. Exp. Immunol. (2005)
- The sweetness of the DNA backbone drives Toll-like receptor 9. Wagner, H. Curr. Opin. Immunol. (2008)
- IL-8 and IDO Expression by Human Gingival Fibroblasts via TLRs. Mahanonda, R., Sa-Ard-Iam, N., Montreekachon, P., Pimkhaokham, A., Yongvanichit, K., Fukuda, M.M., Pichyangkul, S. J. Immunol. (2007)
- High Mobility Group B1 Protein Suppresses the Human Plasmacytoid Dendritic Cell Response to TLR9 Agonists. Popovic, P.J., Demarco, R., Lotze, M.T., Winikoff, S.E., Bartlett, D.L., Krieg, A.M., Guo, Z.S., Brown, C.K., Tracey, K.J., Zeh, H.J. J. Immunol. (2006)
- Heat shock up-regulates TLR9 expression in human B cells through activation of ERK and NF-kappaB signal pathways. Chen, W., Wang, J., An, H., Zhou, J., Zhang, L., Cao, X. Immunol. Lett. (2005)
- Toll-like receptor interactions: tolerance of MyD88-dependent cytokines but enhancement of MyD88-independent interferon-beta production. Broad, A., Kirby, J.A., Jones, D.E. Immunology (2007)
- Expansion of toll-like receptor 9-expressing B cells in active systemic lupus erythematosus: implications for the induction and maintenance of the autoimmune process. Papadimitraki, E.D., Choulaki, C., Koutala, E., Bertsias, G., Tsatsanis, C., Gergianaki, I., Raptopoulou, A., Kritikos, H.D., Mamalaki, C., Sidiropoulos, P., Boumpas, D.T. Arthritis Rheum. (2006)
- Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. Chuang, T.H., Ulevitch, R.J. Nat. Immunol. (2004)
- Toll-like receptors stimulate human neutrophil function. Hayashi, F., Means, T.K., Luster, A.D. Blood (2003)
- The Functional Effects of Physical Interactions among Toll-like Receptors 7, 8, and 9. Wang, J., Shao, Y., Bennett, T.A., Shankar, R.A., Wightman, P.D., Reddy, L.G. J. Biol. Chem. (2006)
- Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide. Liu, S., Gallo, D.J., Green, A.M., Williams, D.L., Gong, X., Shapiro, R.A., Gambotto, A.A., Humphris, E.L., Vodovotz, Y., Billiar, T.R. Infect. Immun. (2002)
- CD40-dependent and -independent activation of human tonsil B cells by CpG oligodeoxynucleotides. Gantner, F., Hermann, P., Nakashima, K., Matsukawa, S., Sakai, K., Bacon, K.B. Eur. J. Immunol. (2003)
- Immunomodulatory oligonucleotides containing a cytosine-phosphate-2'-deoxy-7-deazaguanosine motif as potent toll-like receptor 9 agonists. Kandimalla, E.R., Bhagat, L., Li, Y., Yu, D., Wang, D., Cong, Y.P., Song, S.S., Tang, J.X., Sullivan, T., Agrawal, S. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Toll-like receptors: cellular signal transducers for exogenous molecular patterns causing immune responses. Kirschning, C.J., Bauer, S. Int. J. Med. Microbiol. (2001)
- Bacterial DNA activates human neutrophils by a CpG-independent pathway. Trevani, A.S., Chorny, A., Salamone, G., Vermeulen, M., Gamberale, R., Schettini, J., Raiden, S., Geffner, J. Eur. J. Immunol. (2003)