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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

5 Hz repetitive TMS increases anticipatory motor activity in the human cortex.

In the present study, we analyzed how high-frequency repetitive transcranial magnetic stimulation (rTMS) of the primary motor hand area (M1-Hand) shapes anticipatory motor activity in frontal areas as indexed by the contingent negative variation (CNV). Eight right-handed volunteers received real or sham 5Hz rTMS at an intensity of 90% resting motor threshold (1,500 stimuli per session). Real but not sham rTMS to left M1-Hand induced a site-specific increase in amplitude of the late component of the CNV at the electrode C3 overlaying the site of stimulation. The increase in pre-movement activity in the stimulated cortex may reflect an increase in facilitatory drive from connected motor areas, enhanced responsiveness of the stimulated cortex to these inputs or both.[1]

References

  1. 5 Hz repetitive TMS increases anticipatory motor activity in the human cortex. Holler, I., Siebner, H.R., Cunnington, R., Gerschlager, W. Neurosci. Lett. (2006) [Pubmed]
 
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