Disease relevance of Contingent Negative Variation

• Thirty-three patients with common migraine underwent contingent negative variation (CNV) recordings before receiving prophylactic beta-blocker treatment with either metoprolol (27 patients) or propranolol (6 patients) at mean daily dosages of 110 mg and 122 mg, respectively [1].
• Perimenstrual migraine: effect of Estraderm TTS and the value of contingent negative variation and exteroceptive temporalis muscle suppression test [2].
• To investigate the pathophysiology of idiopathic focal dystonia, we recorded contingent negative variation (CNV) as a physiological index of sensorimotor integration in 14 right-handed patients with writer's cramp and compared it with normative data [3].
• In this study a potential known as the contingent negative variation was used to differentiate between schizophrenic, Parkinson's disease (PD), Huntington's disease (HD) patients and normal control subjects [4].
• To determine whether tinnitus has a masking effect similar to that of general external sounds, the hearing threshold shift when the tinnitus was changed by intravenous administration of lidocaine was measured by contingent negative variation (CNV) audiometry [5].

Psychiatry related information on Contingent Negative Variation

• During hypoglycaemia, ERP measures of selective attention (selection negativity), response choice (lateralized readiness potential) and reaction time were delayed compared with baseline performance [6].
• Studies using the lateralized readiness potential (LRP; an index of hand-specific motor preparation), suggest that the motor system can be activated on the basis of partial information, providing support for a parallel view of the human information processing system [7].
• OBJECTIVES: The authors investigated whether preprogramming (Bereitschaftspotential, BP) and control activity (skilled performance positivity, SPP) in a bimanual, sequential skilled performance task (SPT) is sensitive to L-dopa administration in non-demented Parkinson's disease (PD) patients [8].
• Source errors were not related to performance on the Wisconsin Card Sorting Test, a psychometric index of frontal function, or to the initial orienting response of the contingent negative variation (CNV), a frontally based electrophysiological measure, even though these "frontal" measures were reliably related to each other [9].
• Using event-related potential (ERP) measures of these constructs, we find that only hemisphericity accounts for individual differences in reading skill among our 15-year-old good readers, while the frontally generated Contingent Negative Variation attentional ERP accounts for reading skill differences among the poor readers [10].

High impact information on Contingent Negative Variation

• The goal of this study was to contribute further to this discussion by taking advantage of the increased spatial information of a whole-scalp magnetoencephalography (MEG) system enabling us to record the magnetic equivalent of the Bereitschaftspotential 1, the Bereitschaftsfeld 1 (BF 1) or readiness field 1 [11].
• To investigate the pathophysiology of dystonia, we recorded contingent negative variation (CNV) in 12 patients with cervical dystonia and in 12 age-matched normal subjects [12].
• In support of serial models of speech production, both the lateralized readiness potential, or LRP (related to response preparation), and the N200 (related to response inhibition) measures indicated that conceptual processing began approximately 80 msec earlier than syntactic processing [13].
• Finally, the slow negativity (contingent negative variation/readiness potential) that preceded the target in the "no cue" condition was absent in ADHD patients [14].
• Adinazolam, a triazolobenzodiazepine that has an action similar to antidepressants in several pharmacological tests, was compared with amitriptyline and diazepam in endogenous depressive inpatients exhibiting dexamethasone suppression test non-suppression and/or abnormal contingent negative variation [15].

Chemical compound and disease context of Contingent Negative Variation

• Twelve male outpatients participating in a methadone maintenance treatment program were evaluated for the effects of acute administration of methadone on brain functioning (contingent negative variation or CNV), attention performance (reaction time and continuous performance test), and psychophysiological activity (heart rate and eye blink rate) [16].

Biological context of Contingent Negative Variation

• Evidence is provided for complex cerebral evoked potentials (P300, contingent negative variation) being very sensitive EDS measures comparable to the multiple sleep latency test (MSLT) [17].

Anatomical context of Contingent Negative Variation

• Linear estimation discriminates midline sources and a motor cortex contribution to the readiness potential [18].

Associations of Contingent Negative Variation with chemical compounds

• The present study shows that psychomotor tests and contingent negative variation (CNV), an event related slow cerebral potential, both of which are abnormal in untreated migraineurs, tend to normalize after treatment with the beta blocker metoprolol [19].
• This paper reports the generation of cortical slow potentials (SP), similar to the human contingent negative variation, in rats anaesthetised with urethane [20].
• Recordings of spontaneous EEG and EEG event-related potentials (contingent negative variation) were obtained during both placebo and choline treatments [21].
• Contingent negative variation (CNV) was recorded from electrodes F7, F3, Fz, F4, F8, T7, C3, Cz, C4, T8, P7, P3, Pz, P4 and P8 in 19 young (mean age: 23 years) and 15 elderly (mean age: 66 years) healthy right-handed subjects, using a S2-choice paradigm [22].
• Biphasic dose-related responses of the CNV (contingent negative variation) to I.V. nicotine in man [23].

Gene context of Contingent Negative Variation

• The present set of experiments investigated the Bereitschaftspotential (BP) preceding voluntary bimanual sequential simple (task 1) and complex movements (task 2) in supplementary/cingulate and primary motor areas (SCMA, MIs) using 64-channel direct current electroencephalography analysis in 16 right-handed healthy subjects [24].
• N100, P200, and P300 to the CSs revealed that psychopaths were not deficient in information processing and showed even better anticipatory responding than the HC group indicated by the terminal contingent negative variation (tCNV), that lacked, however, CS+ and CS- differentiation [25].
• Paroxysmal kinesigenic choreoathetosis and abnormal contingent negative variation. A case report [26].
• Using a choice/Nogo task, the utility of the partial information was varied by manipulating the proportion of Go relative to Nogo signals, and preliminary response preparation was indexed by the degree of lateralized readiness potential (LRP) activity on Nogo trials [27].
• Sensorimotor expectancy processes to painful stimulation and motor go/no-go demands were indexed over primary sensorimotor and midline cortical areas by contingent negative variation (CNV) [28].

References