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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Developments in ghrelin biology and potential clinical relevance.

The spiropiperidine, MK0677, has been exploited to characterize and expression clone the growth hormone secretagogue receptor (GHS-R). Cloning of this receptor led to identification of its natural ligands, ghrelin and adenosine. Targeted disruption of the Ghsr gene demonstrated unambiguously that the GH- releasing and orexigenic properties of ghrelin are dependent on Ghsr expression and that the orexigenic signal is mediated through neuropeptide Y and agouti-related peptide neurons. This review summarizes new developments in our understanding of the physiological roles of ghrelin and its receptor (GHS-R). Recent discoveries of the effects of ghrelin on the thymus and proinflammatory and chemotactic cytokine pathways stimulate renewed interest in potential clinical applications, which include age-associated disorders, such as metabolic disease, sarcopenia, congestive heart failure, atherosclerosis and anorexia.[1]


  1. Developments in ghrelin biology and potential clinical relevance. Smith, R.G., Jiang, H., Sun, Y. Trends Endocrinol. Metab. (2005) [Pubmed]
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