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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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UXT is a novel centrosomal protein essential for cell viability.

Ubiquitously expressed transcript (UXT) is a prefoldinlike protein that has been suggested to be involved in human tumorigenesis. Here, we have found that UXT is overexpressed in a number of human tumor tissues but not in the matching normal tissues. We demonstrate that UXT is located in human centrosomes and is associated with gamma-tubulin. In addition, overexpression of UXT disrupts centrosome structure. Furthermore, abrogation of UXT protein expression by small interfering RNA knockdown leads to cell death. Together, our findings suggest that UXT is a component of centrosome and is essential for cell viability. We propose that UXT may facilitate transformation by corrupting regulated centrosome functions.[1]

References

  1. UXT is a novel centrosomal protein essential for cell viability. Zhao, H., Wang, Q., Zhang, H., Liu, Q., Du, X., Richter, M., Greene, M.I. Mol. Biol. Cell (2005) [Pubmed]
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