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Gene Review

UXT  -  ubiquitously-expressed, prefoldin-like...

Homo sapiens

Synonyms: ART-27, Androgen receptor trapped clone 27 protein, HSPC024, Protein UXT, STAP1, ...
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High impact information on UXT

  • In addition, overexpression of UXT disrupts centrosome structure [1].
  • UXT is a novel centrosomal protein essential for cell viability [1].
  • Furthermore, abrogation of UXT protein expression by small interfering RNA knockdown leads to cell death [1].
  • In a systematic search for novel genes, we identified a novel transcript, UXT (HGMW-approved symbol), close to the ELK1 locus in Xp11.23-p11.22 [2].
  • We showed that UXT is ubiquitously expressed and subject to X-inactivation [2].
  • UXT forms a evolutionary conserved prefoldin like complex which contains NNX3, PFD2, PFD4r, PFD6, RPB5, TIP48 and TIP49 [3]

Associations of UXT with chemical compounds

  • Based on these findings, we propose a transcriptional regulatory circuit for the developmental expression of ART-27 that includes repression by chromatin modification through a trichostatin A-sensitive factor and activation upon growth factor stimulation via CREB [4].

Biological context of UXT


Anatomical context of UXT


  1. UXT is a novel centrosomal protein essential for cell viability. Zhao, H., Wang, Q., Zhang, H., Liu, Q., Du, X., Richter, M., Greene, M.I. Mol. Biol. Cell (2005) [Pubmed]
  2. Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue. Schroer, A., Schneider, S., Ropers, H., Nothwang, H. Genomics (1999) [Pubmed]
  3. Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. Gstaiger, M., Luke, B., Hess, D., Oakeley, E.J., Wirbelauer, C., Blondel, M., Vigneron, M., Peter, M., Krek, W. Science. (2003) [Pubmed]
  4. Transcriptional regulation of the androgen receptor cofactor androgen receptor trapped clone-27. Nwachukwu, J.C., Li, W., Pineda-Torra, I., Huang, H.Y., Ruoff, R., Shapiro, E., Taneja, S.S., Logan, S.K., Garabedian, M.J. Mol. Endocrinol. (2007) [Pubmed]
  5. A calcineurin inhibitory protein overexpressed in Down's syndrome interacts with the product of a ubiquitously expressed transcript. Silveira, H.C., Sommer, C.A., Soares-Costa, A., Henrique-Silva, F. Braz. J. Med. Biol. Res. (2004) [Pubmed]
  6. Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells. Liu, L., Amy, V., Liu, G., McKeehan, W.L. In Vitro Cell. Dev. Biol. Anim. (2002) [Pubmed]
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