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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation.

The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence.[1]


  1. Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. Canli, T., Congdon, E., Gutknecht, L., Constable, R.T., Lesch, K.P. Journal of neural transmission (Vienna, Austria : 1996) (2005) [Pubmed]
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