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Acid acclimation by Helicobacter pylori.

Helicobacter pylori is a Gram-negative neutralophile associated with peptic ulcers and gastric cancer. It has a unique ability to colonize the human stomach by acid acclimation. It uses the pH-gated urea channel, UreI, to enhance urea access to intrabacterial urease and a membrane-anchored periplasmic carbonic anhydrase to regulate periplasmic pH to approximately 6.1 in acidic media, whereas other neutralophiles cannot regulate periplasmic pH and thus only transit the stomach.[1]

References

  1. Acid acclimation by Helicobacter pylori. Sachs, G., Weeks, D.L., Wen, Y., Marcus, E.A., Scott, D.R., Melchers, K. Physiology (Bethesda, Md.) (2005) [Pubmed]
 
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