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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Acclimatization


Psychiatry related information on Acclimatization

  • We studied the effect of heat acclimation on the neuromodulatory role of angiotensin (AngII) and nitric oxide during combined heat (39 degrees C) and hypohydration (water deprivation, -10% body weight) stress [6].
  • Oestradiol treatment did not affect rectal temperature in the states of acclimation to thermoneutrality and to cold, nor did it change the hypothermic response of cold-exposed rats to temporary food deprivation [7].
  • The form of the test amino acid (CAA = crystalline, PB = protein-bound) had little effect on choice behavior, but sudden transfer of WCS from a PB acclimation diet to test diets with a large total CAA concentration increased the latency of effective choice by 2-3 days [8].

High impact information on Acclimatization

  • Systemic redox changes in the proximity of photosystem II, hydrogen peroxide, and the induction of antioxidant defenses are key determinants of this mechanism of systemic acquired acclimation [9].
  • AtMYB4 expression is downregulated by exposure to UV-B light, indicating that derepression is an important mechanism for acclimation to UV-B in A.thaliana [10].
  • However, they exhibited increased freezing tolerance after cold acclimation, demonstrating that CAX1 plays an important role in this adaptive response [11].
  • Previous studies established that cold acclimation involves rapid expression of the CBF transcriptional activators (also known as DREB1 proteins) in response to low temperature followed by induction of the CBF regulon (CBF-targeted genes), which contributes to an increase in freezing tolerance [12].
  • HOS10 encodes an R2R3-type MYB transcription factor essential for cold acclimation in plants [13].

Chemical compound and disease context of Acclimatization


Biological context of Acclimatization


Anatomical context of Acclimatization

  • 5. These results indicated a higher oxidative metabolism of skeletal muscle in both cold-acclimated and glucagon-treated than in control ducklings, and for most of the parameters studied, a similarity between cold acclimation and glucagon treatment [24].
  • Increase in the adenine nucleotide translocase content of duckling subsarcolemmal mitochondria during cold acclimation [25].
  • The rapidity of transcript induction and the significant homology with actin-binding proteins (ABP) from different organisms suggest that the product of this gene might be involved in the dynamic reorganization of the cytoskeleton during low temperature acclimation [26].
  • This investigation was designed to determine the relationship between the levels of plasma aldosterone and eccrine sweat gland sodium excretion following exercise and heat acclimation [27].
  • Cadmium exposure and high acclimation temperatures resulted in a strong increase of oxygen demand in gill and hepatopancreas cells of oysters [28].

Associations of Acclimatization with chemical compounds

  • Glucose flux through the shunt was constant at approximately 5 in fed anemones at 5 degrees C and 15 degrees C and in fasted anemones at 15 degrees C, indicating apparently near-perfect thermal acclimation of the absolute flux of glucose through the shunt in fed, but not in fasted, anemones [29].
  • This acclimation is modulated by some mechanisms in the cell to sense CO2 availability [30].
  • Fine-resolution analysis of the lifetime leaf record of an individual birch (Betula pendula) indicates a gradual reduction of stomatal frequency as a phenotypic acclimation to CO2 increase [31].
  • A natural experiment on plant acclimation: lifetime stomatal frequency response of an individual tree to annual atmospheric CO2 increase [31].
  • The extent, path, and site of sucrose metabolism are thus highly responsive to both internal and external environmental signals and can, in turn, dramatically alter development and stress acclimation [32].

Gene context of Acclimatization

  • We propose that the roles of LSD1 in light acclimation and in restricting pathogen-induced cell death are functionally linked [33].
  • Therefore, we conclude that augmentation of SEX1 transcripts might be a homeostatic response to low temperature, and that starch degradation during an early phase of cold acclimation could be regulated by a component(s) of a starch degradation pathway(s) downstream of SEX1 [34].
  • TCH4 is unlikely to play a role in acid-induced wall loosening but may function in cold acclimation or cold-tolerant growth [35].
  • Overexpression of CBF4 in transgenic Arabidopsis plants results in the activation of C-repeat/dehydration-responsive element containing downstream genes that are involved in cold acclimation and drought adaptation [36].
  • The differential stress-responsive regulation of Sus genes in leaves might represent part of a general cellular response to the allocation of carbohydrates during acclimation processes [37].

Analytical, diagnostic and therapeutic context of Acclimatization

  • After 5 to 7 days of acclimation and 2 days of baseline activity recording, rats received a single subcutaneous injection of vehicle (saline) or of 0.6, 2.5, 10 or 40 mg/kg methylphenidate at 08:00, 14:00, 20:00, or 02:00 [38].
  • A heat exercise test (HET), (cycling for 60 min; 50% maximal O2 consumption) was performed before (UN-HET) and after (ACC-HET) the acclimation period [39].
  • Time-courses of the development of freezing tolerance and the expression of a cold-responsive gene wlt10 were monitored during cold acclimation in wheat (Triticum aestivum L.). Bioassay showed that cold acclimation conferred much higher freezing tolerance on a winter cultivar than a spring cultivar [40].
  • The acclimation of the stomatal response to blue light was inversely related to a previously reported acclimation response in which stomata change between high CO2 sensitivity under growth chamber conditions and low CO2 sensitivity under greenhouse conditions [41].
  • Latency to CNS-OT was measured and brain samples were taken for evaluation of heat shock protein 72 (HSP72) levels by Western blot analysis at the end of the acclimation period and during 4 weeks of deacclimation [42].


  1. CBF2/DREB1C is a negative regulator of CBF1/DREB1B and CBF3/DREB1A expression and plays a central role in stress tolerance in Arabidopsis. Novillo, F., Alonso, J.M., Ecker, J.R., Salinas, J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. The nucleic acid melting activity of Escherichia coli CspE is critical for transcription antitermination and cold acclimation of cells. Phadtare, S., Inouye, M., Severinov, K. J. Biol. Chem. (2002) [Pubmed]
  3. PsaK2 subunit in photosystem I is involved in state transition under high light condition in the cyanobacterium Synechocystis sp. PCC 6803. Fujimori, T., Hihara, Y., Sonoike, K. J. Biol. Chem. (2005) [Pubmed]
  4. The UV-B stimulon of the terrestrial cyanobacterium Nostoc commune comprises early shock proteins and late acclimation proteins. Ehling-Schulz, M., Schulz, S., Wait, R., Görg, A., Scherer, S. Mol. Microbiol. (2002) [Pubmed]
  5. Induction of the heat shock protein ClpB affects cold acclimation in the cyanobacterium Synechococcus sp. strain PCC 7942. Porankiewicz, J., Clarke, A.K. J. Bacteriol. (1997) [Pubmed]
  6. Heat acclimation affects the neuromodulatory role of AngII and nitric oxide during combined heat and hypohydration stress. Schwimmer, H., Gerstberger, R., Horowitz, M. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  7. Oxygen consumption of oestradiol-treated rats. Fernández, A., Abelenda, M., Nava, M.P., Puerta, M. Pflugers Arch. (1994) [Pubmed]
  8. Sparrows discriminate between diets differing in valine or lysine concentrations. Murphy, M.E., King, J.R. Physiol. Behav. (1989) [Pubmed]
  9. Systemic signaling and acclimation in response to excess excitation energy in Arabidopsis. Karpinski, S., Reynolds, H., Karpinska, B., Wingsle, G., Creissen, G., Mullineaux, P. Science (1999) [Pubmed]
  10. Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis. Jin, H., Cominelli, E., Bailey, P., Parr, A., Mehrtens, F., Jones, J., Tonelli, C., Weisshaar, B., Martin, C. EMBO J. (2000) [Pubmed]
  11. Mutations in the Ca2+/H+ transporter CAX1 increase CBF/DREB1 expression and the cold-acclimation response in Arabidopsis. Catala, R., Santos, E., Alonso, J.M., Ecker, J.R., Martinez-Zapater, J.M., Salinas, J. Plant Cell (2003) [Pubmed]
  12. Arabidopsis transcriptome profiling indicates that multiple regulatory pathways are activated during cold acclimation in addition to the CBF cold response pathway. Fowler, S., Thomashow, M.F. Plant Cell (2002) [Pubmed]
  13. HOS10 encodes an R2R3-type MYB transcription factor essential for cold acclimation in plants. Zhu, J., Verslues, P.E., Zheng, X., Lee, B.H., Zhan, X., Manabe, Y., Sokolchik, I., Zhu, Y., Dong, C.H., Zhu, J.K., Hasegawa, P.M., Bressan, R.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  14. The role of alterations in membrane lipid composition in enabling physiological adaptation of organisms to their physical environment. Hazel, J.R., Williams, E.E. Prog. Lipid Res. (1990) [Pubmed]
  15. The cardiovascular responses of the red-eared slider (Trachemys scripta) acclimated to either 22 or 5 degrees C. I. Effects of anoxic exposure on in vivo cardiac performance. Hicks, J.M., Farrell, A.P. J. Exp. Biol. (2000) [Pubmed]
  16. Endogenous hormones subtly alter women's response to heat stress. Carpenter, A.J., Nunneley, S.A. J. Appl. Physiol. (1988) [Pubmed]
  17. Changes in carboxysome structure and grouping and in photosynthetic affinity for inorganic carbon in Anabaena strain PCC 7119 (Cyanophyta) in response to modification of CO2 and Na+ supply. Orús, M.I., Rodríguez-Buey, M.L., Marco, E., Fernández-Valiente, E. Plant Cell Physiol. (2001) [Pubmed]
  18. Isolation and characterization of a bacterium possessing a novel aldoxime-dehydration activity and nitrile-degrading enzymes. Kato, Y., Ooi, R., Asano, Y. Arch. Microbiol. (1998) [Pubmed]
  19. Heterothermal acclimation: an experimental paradigm for studying the control of thermal acclimation in crabs. Cuculescu, M., Pearson, T., Hyde, D., Bowler, K. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  20. AtFtsH6 is involved in the degradation of the light-harvesting complex II during high-light acclimation and senescence. Zelisko, A., García-Lorenzo, M., Jackowski, G., Jansson, S., Funk, C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  21. Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold. Golozoubova, V., Hohtola, E., Matthias, A., Jacobsson, A., Cannon, B., Nedergaard, J. FASEB J. (2001) [Pubmed]
  22. Daphnetin methylation by a novel O-methyltransferase is associated with cold acclimation and photosystem II excitation pressure in rye. NDong, C., Anzellotti, D., Ibrahim, R.K., Huner, N.P., Sarhan, F. J. Biol. Chem. (2003) [Pubmed]
  23. The AGUAAA motif in cspA1/A2 mRNA is important for adaptation of Yersinia enterocolitica to grow at low temperature. Neuhaus, K., Anastasov, N., Kaberdin, V., Francis, K.P., Miller, V.L., Scherer, S. Mol. Microbiol. (2003) [Pubmed]
  24. Histochemical arguments for muscular non-shivering thermogenesis in muscovy ducklings. Duchamp, C., Cohen-Adad, F., Rouanet, J.L., Barré, H. J. Physiol. (Lond.) (1992) [Pubmed]
  25. Increase in the adenine nucleotide translocase content of duckling subsarcolemmal mitochondria during cold acclimation. Roussel, D., Chainier, F., Rouanet, J., Barré, H. FEBS Lett. (2000) [Pubmed]
  26. Identification and characterization of a low temperature regulated gene encoding an actin-binding protein from wheat. Danyluk, J., Carpentier, E., Sarhan, F. FEBS Lett. (1996) [Pubmed]
  27. Plasma aldosterone and sweat sodium concentrations after exercise and heat acclimation. Kirby, C.R., Convertino, V.A. J. Appl. Physiol. (1986) [Pubmed]
  28. Effects of acclimation temperature and cadmium exposure on cellular energy budgets in the marine mollusk Crassostrea virginica: linking cellular and mitochondrial responses. Cherkasov, A.S., Biswas, P.K., Ridings, D.M., Ringwood, A.H., Sokolova, I.M. J. Exp. Biol. (2006) [Pubmed]
  29. Allozymes of glucose-6-phosphate isomerase differentially modulate pentose-shunt metabolism in the sea anemone Metridium senile. Zamer, W.E., Hoffmann, R.J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  30. Ccm1, a regulatory gene controlling the induction of a carbon-concentrating mechanism in Chlamydomonas reinhardtii by sensing CO2 availability. Fukuzawa, H., Miura, K., Ishizaki, K., Kucho, K.I., Saito, T., Kohinata, T., Ohyama, K. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  31. A natural experiment on plant acclimation: lifetime stomatal frequency response of an individual tree to annual atmospheric CO2 increase. Wagner, F., Below, R., Klerk, P.D., Dilcher, D.L., Joosten, H., Kürschner, W.M., Visscher, H. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  32. Sucrose metabolism: regulatory mechanisms and pivotal roles in sugar sensing and plant development. Koch, K. Curr. Opin. Plant Biol. (2004) [Pubmed]
  33. LESION SIMULATING DISEASE 1 is required for acclimation to conditions that promote excess excitation energy. Mateo, A., Mühlenbock, P., Rustérucci, C., Chang, C.C., Miszalski, Z., Karpinska, B., Parker, J.E., Mullineaux, P.M., Karpinski, S. Plant Physiol. (2004) [Pubmed]
  34. Starch-related alpha-glucan/water dikinase is involved in the cold-induced development of freezing tolerance in Arabidopsis. Yano, R., Nakamura, M., Yoneyama, T., Nishida, I. Plant Physiol. (2005) [Pubmed]
  35. The Arabidopsis TCH4 xyloglucan endotransglycosylase. Substrate specificity, pH optimum, and cold tolerance. Purugganan, M.M., Braam, J., Fry, S.C. Plant Physiol. (1997) [Pubmed]
  36. Transcription factor CBF4 is a regulator of drought adaptation in Arabidopsis. Haake, V., Cook, D., Riechmann, J.L., Pineda, O., Thomashow, M.F., Zhang, J.Z. Plant Physiol. (2002) [Pubmed]
  37. Sugar/osmoticum levels modulate differential abscisic acid-independent expression of two stress-responsive sucrose synthase genes in Arabidopsis. Déjardin, A., Sokolov, L.N., Kleczkowski, L.A. Biochem. J. (1999) [Pubmed]
  38. Methylphenidate: diurnal effects on locomotor and stereotypic behavior in the rat. Gaytan, O., Ghelani, D., Martin, S., Swann, A., Dafny, N. Brain Res. (1997) [Pubmed]
  39. Substrate utilization in leg muscle of men after heat acclimation. Kirwan, J.P., Costill, D.L., Kuipers, H., Burrell, M.J., Fink, W.J., Kovaleski, J.E., Fielding, R.A. J. Appl. Physiol. (1987) [Pubmed]
  40. Expression of a cold-responsive Lt-Cor gene and development of freezing tolerance during cold acclimation in wheat (Triticum aestivum L.). Ohno, R., Takumi, S., Nakamura, C. J. Exp. Bot. (2001) [Pubmed]
  41. The blue light-specific response of Vicia faba stomata acclimates to growth environment. Frechilla, S., Talbott, L.D., Zeiger, E. Plant Cell Physiol. (2004) [Pubmed]
  42. Heat acclimation prolongs the time to central nervous system oxygen toxicity in the rat. Possible involvement of HSP72. Arieli, Y., Eynan, M., Gancz, H., Arieli, R., Kashi, Y. Brain Res. (2003) [Pubmed]
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