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MeSH Review

Peptic Ulcer

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Disease relevance of Peptic Ulcer


Psychiatry related information on Peptic Ulcer

  • The more convenient dosage schedule of ranitidine may be important for patient compliance with initial therapy of peptic ulcer disease, and the greater duration of ranitidine antisecretory effects may enhance effectiveness of long-term maintenance therapy by providing more complete inhibition of nocturnal acid secretion [6].
  • Proton-pump inhibitor treatment resulted in an absolute risk reduction of peptic ulcer by 36.6% in acute and 34.6% in chronic non-steroidal anti-inflammatory drugs/aspirin users; indeed, the number needed to treat to avoid one peptic ulcer in elderly non-steroidal anti-inflammatory drugs/aspirin users was three both in acute and chronic users [7].
  • Over the followup period, patients with RA had a higher likelihood of developing congestive heart failure, chronic pulmonary disease, dementia, and peptic ulcer disease, while cases with OA had a significantly higher risk of developing peptic ulcer disease and renal disease [8].
  • The following factors seemed to have no influence on rates of ulcer healing: age, sex, duration of ulcer disease, duration (beyond four weeks) of cimetidine therapy, family history of peptic ulcer, alcohol consumption, and coffee consumption [9].
  • OBJECTIVE: The evolution of views regarding the impact of psychosocial factors on peptic ulcer was traced by examining all articles related to the upper gastrointestinal tract published in Psychosomatic Medicine since its inception [10].

High impact information on Peptic Ulcer


Chemical compound and disease context of Peptic Ulcer


Biological context of Peptic Ulcer


Anatomical context of Peptic Ulcer


Gene context of Peptic Ulcer


Analytical, diagnostic and therapeutic context of Peptic Ulcer


  1. Effect of acid suppression on efficacy of treatment for Helicobacter pylori infection. de Boer, W., Driessen, W., Jansz, A., Tytgat, G. Lancet (1995) [Pubmed]
  2. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology. Crabtree, J.E., Taylor, J.D., Wyatt, J.I., Heatley, R.V., Shallcross, T.M., Tompkins, D.S., Rathbone, B.J. Lancet (1991) [Pubmed]
  3. Effect of somatostatin on splanchnic hemodynamics in patients with cirrhosis of the liver and in normal subjects. Sonnenberg, G.E., Keller, U., Perruchoud, A., Burckhardt, D., Gyr, K. Gastroenterology (1981) [Pubmed]
  4. A randomized trial comparing the effect of rofecoxib, a cyclooxygenase 2-specific inhibitor, with that of ibuprofen on the gastroduodenal mucosa of patients with osteoarthritis.Rofecoxib Osteoarthritis Endoscopy Study Group. Laine, L., Harper, S., Simon, T., Bath, R., Johanson, J., Schwartz, H., Stern, S., Quan, H., Bolognese, J. Gastroenterology (1999) [Pubmed]
  5. Aspects of the natural history of gastrointestinal bleeding in cirrhosis and the effect of prednisone. Christensen, E., Fauerholdt, L., Schlichting, P., Juhl, E., Poulsen, H., Tygstrup, N. Gastroenterology (1981) [Pubmed]
  6. Review of peptic ulcer maintenance trials. Robinson, M. Am. J. Med. (1984) [Pubmed]
  7. Proton-pump inhibitors reduce the risk of uncomplicated peptic ulcer in elderly either acute or chronic users of aspirin/non-steroidal anti-inflammatory drugs. Pilotto, A., Franceschi, M., Leandro, G., Paris, F., Cascavilla, L., Longo, M.G., Niro, V., Andriulli, A., Scarcelli, C., Di Mario, F. Aliment. Pharmacol. Ther. (2004) [Pubmed]
  8. Comorbidity in arthritis. Gabriel, S.E., Crowson, C.S., O'Fallon, W.M. J. Rheumatol. (1999) [Pubmed]
  9. Unsuccessful cimetidine treatment of peptic ulcer: analysis of the factors involved. Granelli, P., Angelini, G.P., Celli, L. Clinical therapeutics. (1984) [Pubmed]
  10. Bellyaching in these pages: upper gastrointestinal disorders in Psychosomatic medicine. Levenstein, S. Psychosomatic medicine. (2002) [Pubmed]
  11. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. Lau, J.Y., Sung, J.J., Lee, K.K., Yung, M.Y., Wong, S.K., Wu, J.C., Chan, F.K., Ng, E.K., You, J.H., Lee, C.W., Chan, A.C., Chung, S.C. N. Engl. J. Med. (2000) [Pubmed]
  12. Famotidine to prevent peptic ulcer caused by NSAIDs. Graham, D.Y. N. Engl. J. Med. (1996) [Pubmed]
  13. Misoprostol for the treatment of peptic ulcer and antiinflammatory-drug-induced gastroduodenal ulceration. Walt, R.P. N. Engl. J. Med. (1992) [Pubmed]
  14. Controlled trial of methylprednisolone and chlorambucil in idiopathic membranous nephropathy. Ponticelli, C., Zucchelli, P., Imbasciati, E., Cagnoli, L., Pozzi, C., Passerini, P., Grassi, C., Limido, D., Pasquali, S., Volpini, T. N. Engl. J. Med. (1984) [Pubmed]
  15. Association of adrenocorticosteroid therapy and peptic-ulcer disease. Messer, J., Reitman, D., Sacks, H.S., Smith, H., Chalmers, T.C. N. Engl. J. Med. (1983) [Pubmed]
  16. A comparison of omeprazole and placebo for bleeding peptic ulcer. Khuroo, M.S., Yattoo, G.N., Javid, G., Khan, B.A., Shah, A.A., Gulzar, G.M., Sodi, J.S. N. Engl. J. Med. (1997) [Pubmed]
  17. Gastric acid secretion and lower-esophageal-sphincter pressure in response to coffee and caffeine. Cohen, S., Booth, G.H. N. Engl. J. Med. (1975) [Pubmed]
  18. Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Jones, M.K., Wang, H., Peskar, B.M., Levin, E., Itani, R.M., Sarfeh, I.J., Tarnawski, A.S. Nat. Med. (1999) [Pubmed]
  19. Spontaneous stomach ulcer in genetically mast-cell depleted W/Wv mice. Shimada, M., Kitamura, Y., Yokoyama, M., Miyano, Y., Maeyama, K., Yamatodani, A., Takahashi, Y., Tatsuta, M. Nature (1980) [Pubmed]
  20. Bronchodilator effects on gastric acid secretion. Foster, L.J., Trudeau, W.L., Goldman, A.L. JAMA (1979) [Pubmed]
  21. Geographic distribution of vacA allelic types of Helicobacter pylori. Van Doorn, L.J., Figueiredo, C., Mégraud, F., Pena, S., Midolo, P., Queiroz, D.M., Carneiro, F., Vanderborght, B., Pegado, M.D., Sanna, R., De Boer, W., Schneeberger, P.M., Correa, P., Ng, E.K., Atherton, J., Blaser, M.J., Quint, W.G. Gastroenterology (1999) [Pubmed]
  22. Helicobacter pylori VacA cytotoxin: a probe for a clathrin-independent and Cdc42-dependent pinocytic pathway routed to late endosomes. Gauthier, N.C., Monzo, P., Kaddai, V., Doye, A., Ricci, V., Boquet, P. Mol. Biol. Cell (2005) [Pubmed]
  23. A prospective randomized comparative trial showing that omeprazole prevents rebleeding in patients with bleeding peptic ulcer after successful endoscopic therapy. Lin, H.J., Lo, W.C., Lee, F.Y., Perng, C.L., Tseng, G.Y. Arch. Intern. Med. (1998) [Pubmed]
  24. Hypertension corrected by discontinuing chronic sodium bicarbonate ingestion. Subsequent transient hypoaldosteronism. Lowder, S.C., Brown, R.D. Am. J. Med. (1975) [Pubmed]
  25. Trends in morbidity and mortality from peptic ulcer disease: Tayside versus Scotland. Penston, J.G., Crombie, I.K., Waugh, N.R., Wormsley, K.G. Aliment. Pharmacol. Ther. (1993) [Pubmed]
  26. Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs. Langman, M.J., Jensen, D.M., Watson, D.J., Harper, S.E., Zhao, P.L., Quan, H., Bolognese, J.A., Simon, T.J. JAMA (1999) [Pubmed]
  27. Importance of gastric acid in gastric ulcer formation in rabbits with antibody-induced prostaglandin deficiency. Lee, M., Aldred, K., Lee, E., Prince, M.D., Feldman, M. Gastroenterology (1992) [Pubmed]
  28. Effect of cimetidine on the gastric bacterial flora. Ruddell, W.S., Axon, A.T., Findlay, J.M., Bartholomew, B.A., Hill, M.J. Lancet (1980) [Pubmed]
  29. Role of epidermal growth factor in healing of chronic gastroduodenal ulcers in rats. Konturek, S.J., Dembinski, A., Warzecha, Z., Brzozowski, T., Gregory, H. Gastroenterology (1988) [Pubmed]
  30. Reduced tissue type plasminogen activator activity of the gastroduodenal mucosa in peptic ulcer disease. Wodziński, M.A., Bardhan, K.D., Reilly, J.T., Cooper, P., Preston, F.E. Gut (1993) [Pubmed]
  31. The cardiac K+ channel KCNQ1 is essential for gastric acid secretion. Grahammer, F., Herling, A.W., Lang, H.J., Schmitt-Gräff, A., Wittekindt, O.H., Nitschke, R., Bleich, M., Barhanin, J., Warth, R. Gastroenterology (2001) [Pubmed]
  32. The significance of gastrin in the pathogenesis and therapy of peptic ulcer disease. Lamers, C.B. Drugs (1988) [Pubmed]
  33. Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors. Jüttner, S., Cramer, T., Wessler, S., Walduck, A., Gao, F., Schmitz, F., Wunder, C., Weber, M., Fischer, S.M., Schmidt, W.E., Wiedenmann, B., Meyer, T.F., Naumann, M., Höcker, M. Cell. Microbiol. (2003) [Pubmed]
  34. Anti-ulcerogenic properties of endothelin receptor antagonists in the rat. Padol, I., Huang, J.Q., Hunt, R.H. Aliment. Pharmacol. Ther. (1999) [Pubmed]
  35. The polymorphic IL-1B and IL-1RN genes in the aetiopathogenesis of peptic ulcer. Garcia-Gonzalez, M.A., Lanas, A., Santolaria, S., Crusius, J.B., Serrano, M.T., Peña, A.S. Clin. Exp. Immunol. (2001) [Pubmed]
  36. Estrogen predisposes to cholecystectomy but not to stones. Everson, R.B., Byar, D.P., Bischoff, A.J. Gastroenterology (1982) [Pubmed]
  37. Time trends in peptic ulcer surgery, 1956 to 1986. A nation-wide survey in Sweden. Gustavsson, S., Nyrén, O. Ann. Surg. (1989) [Pubmed]
  38. The Helicobacter pylori breath test: a surrogate marker for peptic ulcer disease in dyspeptic patients. McColl, K.E., el-Nujumi, A., Murray, L., el-Omar, E., Gillen, D., Dickson, A., Kelman, A., Hilditch, T.E. Gut (1997) [Pubmed]
  39. Transthoracic vagotomy for postoperative peptic ulcer. Effects on basal, sham feeding- and pentagastrin-stimulated acid secretion, and on clinical outcome. Thirlby, R.C., Feldman, M. Ann. Surg. (1985) [Pubmed]
  40. Endoscopic injection sclerosis: effective treatment for bleeding peptic ulcer. Rajgopal, C., Palmer, K.R. Gut (1991) [Pubmed]
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