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Fukushima, A. et al.

Fukushima, Yamaguchi, Ishida, Fukata, Yagita, Ueno,

The interaction between ICOS and B7RP-1 is not required for the development of experimental murine allergic conjunctivitis.

It is still unclear whether the interaction between inducible costimulator (ICOS) and its ligand, B7 related protein (B7RP)-1, is important for the development of allergic diseases. We investigated whether blocking the ICOS/B7RP-1 interaction affects the development of murine experimental allergic conjunctivitis (EC). EC was induced in Balb/c mice either by active immunization of ragweed (RW) or by transferring RW-primed splenocytes, followed by challenge with RW-containing eye drops. The mice were treated with anti-B7RP-1 antibody (Ab) or normal rat immunoglobulin G (IgG) during either the induction or effector phase. Regardless of the induction method or when the animals were treated, eosinophil infiltration into the conjunctiva was not affected by the anti-B7RP-1 Ab treatment. Splenocyte responses were not largely affected by this treatment. However, serum Ig levels were significantly reduced. These data suggest that blocking the ICOS/B7RP-1 in allergic diseases may not always be therapeutic.[1]

References

The interaction between ICOS and B7RP-1 is not required for the development of experimental murine allergic conjunctivitis. Fukushima, A., Yamaguchi, T., Ishida, W., Fukata, K., Yagita, H., Ueno, H. Biochem. Biophys. Res. Commun. (2005) [Pubmed]

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